Styrene is a chemical monomer (precursor to a polymer) used in the common industrial production of polystyrene products such as Styrofoam. Styrene monomer is a volatile chemical which can be toxic when inhaled in large quantities. The following blood styrene measurements were made in human volunteers exposed to 80 ppm styrene monomer for 6 hr. Time, t (hr) 1.5 Blood Styrene Levels (ug/ml) 0.450 2.5 0.767 4 0.794 5 0.853 6 0.916 6.5 0.519 7 0.314 8 0.185 10 0.074 12 0.062 14 0.055 18 0.036 23 0.028 30 0.019 47 0.006 Analyze this data and perform the necessary calculations to determine the following pharmacokinetic parameters from the inhaled Styrene data: (5 points per parameter, 18 parameters/variables = 90 points possible). You do NOT need to submit graphs or data tables. Give the terminal regression line equation and R or R² value: Give the x axis (name and units, if any) of the terminal line: Give the y axis (name and units, if any) of the terminal line: Give the residual regression line equation and R or R² value: Give the x axis (name and units, if any) of the residual line: Give the y axis (name and units, if any) of the residual line:
Styrene is a chemical monomer (precursor to a polymer) used in the common industrial production of polystyrene products such as Styrofoam. Styrene monomer is a volatile chemical which can be toxic when inhaled in large quantities. The following blood styrene measurements were made in human volunteers exposed to 80 ppm styrene monomer for 6 hr. Time, t (hr) 1.5 Blood Styrene Levels (ug/ml) 0.450 2.5 0.767 4 0.794 5 0.853 6 0.916 6.5 0.519 7 0.314 8 0.185 10 0.074 12 0.062 14 0.055 18 0.036 23 0.028 30 0.019 47 0.006 Analyze this data and perform the necessary calculations to determine the following pharmacokinetic parameters from the inhaled Styrene data: (5 points per parameter, 18 parameters/variables = 90 points possible). You do NOT need to submit graphs or data tables. Give the terminal regression line equation and R or R² value: Give the x axis (name and units, if any) of the terminal line: Give the y axis (name and units, if any) of the terminal line: Give the residual regression line equation and R or R² value: Give the x axis (name and units, if any) of the residual line: Give the y axis (name and units, if any) of the residual line:
Chapter10: Reconstitution Of Powdered Drugs
Section: Chapter Questions
Problem 42SST
Related questions
Question
Biopharmaceutics and Pharmacokinetics:Two-Compartment Model Zero-Order Absorption Questions
SHOW ALL WORK, including equation used, variables used and each step to your solution, report your regression lines and axes names (with units if appropriate) :Calculate a-q
a) B1,
b) B2,
c) hybrid rate constant (1)
d) hybrid rate constant (2)
e) t1/2,dist
f) t1/2,elim
g) k10
h) k12
i) k21
j) initial concentration (C0)
k) central compartment volume (V1)
l) steady-state volume (Vss)
m) clearance (CL) AUC (0→10 min) using trapezoidal rule
n) AUC (20→30 min) using trapezoidal rule
o) AUCtail (AUC360→∞)
p) total AUC (using short cut method)
q) volume from AUC (VAUC)
Transcribed Image Text:Styrene is a chemical monomer (precursor to a polymer) used in the common industrial production
of polystyrene products such as Styrofoam. Styrene monomer is a volatile chemical which can be
toxic when inhaled in large quantities. The following blood styrene measurements were made in
human volunteers exposed to 80 ppm styrene monomer for 6 hr.
Time, t (hr)
1.5
Blood Styrene Levels (ug/ml)
0.450
2.5
0.767
4
0.794
5
0.853
6
0.916
6.5
0.519
7
0.314
8
0.185
10
0.074
12
0.062
14
0.055
18
0.036
23
0.028
30
0.019
47
0.006
Analyze this data and perform the necessary calculations to determine the following pharmacokinetic
parameters from the inhaled Styrene data: (5 points per parameter, 18 parameters/variables = 90
points possible). You do NOT need to submit graphs or data tables.
Give the terminal regression line equation and R or R² value:
Give the x axis (name and units, if any) of the terminal line:
Give the y axis (name and units, if any) of the terminal line:
Transcribed Image Text:Give the residual regression line equation and R or R² value:
Give the x axis (name and units, if any) of the residual line:
Give the y axis (name and units, if any) of the residual line:
Expert Solution
This question has been solved!
Explore an expertly crafted, step-by-step solution for a thorough understanding of key concepts.
Step by step
Solved in 2 steps
Recommended textbooks for you
Essentials of Pharmacology for Health Professions
Nursing
ISBN:
9781305441620
Author:
WOODROW
Publisher:
Cengage
Essentials of Pharmacology for Health Professions
Nursing
ISBN:
9781305441620
Author:
WOODROW
Publisher:
Cengage
Nutrition Through The Life Cycle
Health & Nutrition
ISBN:
9781337919333
Author:
Brown, Judith E.
Publisher:
Cengage Learning,
Human Physiology: From Cells to Systems (MindTap …
Biology
ISBN:
9781285866932
Author:
Lauralee Sherwood
Publisher:
Cengage Learning