Gluconeogenesis involves the synthesis of glucose from non-carbohydrate precursors. The organs most active from the perspective of gluconeogenesis are the liver and the kidney, which supply glucose to the organs that cannot synthesize it, yet have a strict need for glucose as an energy source.   Gluconeogenesis requires several equilibrium steps of glycolysis to run in the reverse direction.  What are the reactants and products when GAPDH runs in the direction of gluconeogenesis       Glycolysis as a ten-step pathway from glucose to pyruvate is Favourable. Is gluconeogenesis favourable under standard conditions (ie. is the ΔGo’ for the pathway negative)?         c.  What is true about the thermodynamics of the regulated steps in glycolysis.  Compare ΔG and ΔGo’  for those steps in both directions.

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