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2. A growing understanding of how proteins fold allows researchers to make predictions about protein structure from sequence data alone. Use your knowledge of protein structure to make predictions about the secondary and tertiary structure of the following 28-residue amino acid sequence. a. Where might an intrachain disulfide bond form? 1 2 3 4 5 6 7 89 10 Ile-Ala-His-Thr-Tyr-Gly-Pro-Phe-Glu-Ala 11 12 13 14 15 16 17 18 19 20 Ala-Met-Cys-Lys-Trp-Glu-Ala-Gln-Pro-Asp- 21 22 23 24 25 26 27 28 Gly-Met-Glu-Cys-Ala-Phe-His-Arg b. If this sequence is part of a larger protein, where would you expect to find each of the following amino acid residues, (Asp, Ile, Thr, Ala, Gin, Lys, Phe) On the surface of the protein, or buried in its core? Why? c. Name a few pairs of residues that could form salt bridges (electrostatic interactions) at pH=7.4. d. Would you expect this amino acid sequence to be positively or negatively charged at pH=7.4?

2. A growing understanding of how proteins fold allows researchers to make predictions about protein structure from sequence data alone. Use your knowledge of protein structure to make predictions about the secondary and tertiary structure of the following 28-residue amino acid sequence. a. Where might an intrachain disulfide bond form? 1 2 3 4 5 6 7 89 10 Ile-Ala-His-Thr-Tyr-Gly-Pro-Phe-Glu-Ala 11 12 13 14 15 16 17 18 19 20 Ala-Met-Cys-Lys-Trp-Glu-Ala-Gln-Pro-Asp- 21 22 23 24 25 26 27 28 Gly-Met-Glu-Cys-Ala-Phe-His-Arg b. If this sequence is part of a larger protein, where would you expect to find each of the following amino acid residues, (Asp, Ile, Thr, Ala, Gin, Lys, Phe) On the surface of the protein, or buried in its core? Why? c. Name a few pairs of residues that could form salt bridges (electrostatic interactions) at pH=7.4. d. Would you expect this amino acid sequence to be positively or negatively charged at pH=7.4?

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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2. A growing understanding of how proteins fold allows researchers to make predictions about protein structure from sequence data alone. Use your knowledge of protein structure to make predictions about the secondary and tertiary structure of the following 28-residue amino acid sequence. a. Where might an intrachain disulfide bond form? 1 2 3 4 5 6 7 89 10 Ile-Ala-His-Thr-Tyr-Gly-Pro-Phe-Glu-Ala 11 12 13 14 15 16 17 18 19 20 Ala-Met-Cys-Lys-Trp-Glu-Ala-Gln-Pro-Asp- 21 22 23 24 25 26 27 28 Gly-Met-Glu-Cys-Ala-Phe-His-Arg b. If this sequence is part of a larger protein, where would you expect to find each of the following amino acid residues, (Asp, Ile, Thr, Ala, Gin, Lys, Phe) On the surface of the protein, or buried in its core? Why? c. Name a few pairs of residues that could form salt bridges (electrostatic interactions) at pH=7.4. d. Would you expect this amino acid sequence to be positively or negatively charged at pH=7.4?
Transcribed Image Text:2. A growing understanding of how proteins fold allows researchers to make predictions about protein structure from sequence data alone. Use your knowledge of protein structure to make predictions about the secondary and tertiary structure of the following 28-residue amino acid sequence. a. Where might an intrachain disulfide bond form? 1 2 3 4 5 6 7 89 10 Ile-Ala-His-Thr-Tyr-Gly-Pro-Phe-Glu-Ala 11 12 13 14 15 16 17 18 19 20 Ala-Met-Cys-Lys-Trp-Glu-Ala-Gln-Pro-Asp- 21 22 23 24 25 26 27 28 Gly-Met-Glu-Cys-Ala-Phe-His-Arg b. If this sequence is part of a larger protein, where would you expect to find each of the following amino acid residues, (Asp, Ile, Thr, Ala, Gin, Lys, Phe) On the surface of the protein, or buried in its core? Why? c. Name a few pairs of residues that could form salt bridges (electrostatic interactions) at pH=7.4. d. Would you expect this amino acid sequence to be positively or negatively charged at pH=7.4?
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