Provide a step-by-step mechanism of the formation of the epoxy intermediate, starting with the Cyctochrome P450 high valent iron-oxo intermediate as your oxidant
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Provide a step-by-step mechanism of the formation of the epoxy intermediate, starting with the Cyctochrome P450 high valent iron-oxo intermediate as your oxidant
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- One of the steps in psilocybin biosynthesis is the phosphorylation of 4-hydroxytryptamine By the enzyme Psik as shown below, that involves the hydrolysis of ATP. NH₂ OH HO Psik HO of A& ADP 4-hydroxytryptamine ATP norbaeocystin The standard free energy changes for each reaction is shown in the Table below. J reaction 4-hydroxytryptamine + P₁ → norbaeocystin ATP → ADP+ Pi (b) What is the equilibrium constant at 37 °C? AG 27.7 kJ/mol -32.2 kJ/mol (a) Write the net reaction. What is the standard free energy change for the net reaction? (c) In the cell, the concentration of ATP is 3.1 mM, the concentration of P; Is 5.90 mM, and the Concentration of ADP is 220 μM. What will AG Be if the concentration of norbaeocystin Is always kept at 1/100 of the concentration of 4-hydroxytryptamine?The following image is a schematic of the metabolic processes occurring in a plant contained in a closed container. A=Light Dependent reactions B=Glycolysis C=Light Independent Reactions D=Kreb's cycle E=electron transport chain 2a) Use the figure above to explain the conditions in which the oxygen concentration remains constant in the container. b) 2-carboxyarabinitol-1,5-bisphosphate (CABP) is an inhibitor of the enzyme rubisco. Which pathway would this affect most?Which of the following statements regarding the active site of cytochrome P450s is correct? Cytochrome P450-catalyzed monooxygenation proceeds with low stereoselectivity Cytochrome P450-catalyzed monooxygenation requires two electrons supplied by the redox process involving NADPH and NADP+. The 5th distal position (below the plane of the porphyrin ring) in cytochrome P450 is always occupied by His Cytochrome P450 is responsible for the metabolism of the minority of prescription drugs Cytochrome P450 contains manganese
- The photosynthetic process used by the green sulfur bacteria, under anaerobic conditions, is best represented by which of the following balanced equations? cell bio 6CO2 + 12H2S C6H12O6 + 6S2 + 6H2O C6H12O6 + C6H12O6 C12H22O11 + H2O 6CO2 + 12H2O C6H12O6 + 6O2 + 6H2O C12H22O11 + H2O C6H12O6 + C6H12O6 C6H12O6 + 6O2 + 6H2O 6CO2 + 12H2OCytochrome P450 (CYP450) monoxygenase is the enzyme involved in Phase I metabolism. 450 refers to: * It can metabolize 450 drugs when in the reduced form and complexed to carbon monoxide It can produce 450 drugs when in the oxidized form and complexed to carbon dioxide It can emit light at 450 nm when in the oxidized form and complexed to carbon monoxide It can absorb light at 450 nm when in the reduced form and complexed to carbon dioxide It can absorb light at 450 nm when in the reduced form and complexed to carbon monoxideAn organism is fed 14C-labeled acetic acid; the acetic acid is labeled at the 2-carbon(the methyl group carbon). Hint: Go to the Sigma-Aldrich Corporation page on isoprenebiosynthesis and look at the mevalonate pathway. Note that the acetic acid is convertedto acetyl-CoA prior to entering the pathway.Which carbons would contain the radioactive-labeled in the isoprene produced by themevalonate pathway? Circle them, and show how you derived the answer.
- Inorganic Nitrate (N03-) contaminated the soil around their plant. Scientists developed mechanisms for removing Nitrite (N02-) from the soil, but have not found one for Nitrate (N03-). Is there any types of bacteria that could metabolize Nitrate (N03-) to give rise to Nitrite (N02-)? Indicate ALL metabolic pathways that could be used (aerobic respiration, anaerobic respiration, aerobic chemolithotrophy, and anaerobic chemolithotrophy) to carry out this reaction? Which of these reactions can oxidize or reduce inorganic materialsAll of the following is correct about folate and vitamin B12 involvement in resynthesis of methionine from homocysteine except: Cobalamin acts as a methyl donor by giving the methyl group to 5-methyl THF Methylcobalamin give a methyl group to homocysteine to form methionine and reform cobalamin 5, 10-methylene THF is converted to 5-methyl THF by methylene THF reductase The involvement of folate and vitamin B12occurs in the cytosol.Honey bees have a well characterized gut microbiome. One of the species identified carries a gene for a protein called acetate:succinate CoA-transferase (ASCT) which catalyzes the reaction : acetate + Succinyl-CoA acetylCoA and succinate. What step in the TCA cycle is bypassed by this enzyme? How does that affect the yield of NTPs in the TCA cycle? What is the advantage of having this enzyme? Under what conditions would it be useful Would this enzyme allow the bacteria to synthesize glucose from 2 carbon precursors?
- Referring to figure 5 and 8 which substrate molecule serves as the phosphate donor during substrate-level phosphorylation in step 10 of glycosis and the succinyl CoA-succinate step of the Krebs Cycle?In order to break the carbon-carbon bond of Acetyl-CoA in a way that does not harm the cell, citrate is produced in the TCA cycle. Explain how switching between 6-carbon, 5-carbon and 4-carbon metabolites eventually allows the two carbons of Acetyl-CoA to be converted to CO2 in a way that does not harm the cell.Figure 17.9 shows the steps in the pyruvate dehydrogenase complex reaction cycle. A key product, acetyl CoA, is released after the fourth step. What is the purpose of the remaining steps?