Biochemistry
6th Edition
ISBN: 9781305577206
Author: Reginald H. Garrett, Charles M. Grisham
Publisher: Cengage Learning
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Chapter 18, Problem 24P
Based on your knowledge of the structure of NAD+ and an assumption that coenzyme dissociation is the rate limiting step of the alcohol dehydrogenase mechanism, hypothesize why a N249W mutation at the coenzyme binding site would increase the rate of catalysis.
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3. Which one of the compounds
below is the major product formed by
the reaction sequence shown here?
CH3 +
CH3NO2
NaOH
H2, Ni
?
nitromethane
acetophenone
OH
OH
HO HN-
u x x x x
Ph
A
HO
-NH2
HO
H
Ph
Ph
Ph
N-
H
B
Ph
NH2
D
E
4. Only ONE of the five compounds below can be prepared by an aldol condensation in
which a single carbonyl compound is treated with base. Which one is it?
To solve this problem, reverse the aldol condensation that formed each of these molecules to find out what two molecules
came together to make the products. The one in which the two molecules are identical is the answer.
Ph
Ph
ཚིག གནས ག ནཱ ཀ ན ཀནཱ
A
Ph
H
B
Ph
Ph
H
D
Ph.
Ph
Ph
E
H
5. Which one is the major organic
product obtained from the following
reaction sequence?
First, equimolar amounts of cyclopentanone and
LDA are mixed at -78°C. Then propionaldehyde
(propanal) is added. Addition of aqueous acid
completes the process.
LDA, -78°C.
1.
2. H₂O*
H
A
B
H
0
D
H
H
E
Chapter 18 Solutions
Biochemistry
Ch. 18 - Characterizing Glycolysis List the reactions of...Ch. 18 - Radiotracer Labeling of Pyruvate from Glucose...Ch. 18 - Effects of Changing Metabolite Concentrations on...Ch. 18 - Prob. 4PCh. 18 - Prob. 5PCh. 18 - The Reactions and Meehanisms of the Leloir Pathway...Ch. 18 - The Effect of lodoacetic Acid on the...Ch. 18 - Prob. 8PCh. 18 - Comparing Glycolysis Entry Points for Sucrose...Ch. 18 - Prob. 10P
Ch. 18 - Prob. 11PCh. 18 - Prob. 12PCh. 18 - Prob. 13PCh. 18 - Energetic of Fructose-1 ,6-bis P Hydrolysis...Ch. 18 - Prob. 15PCh. 18 - Energetics of the Hexokinase Reaction The...Ch. 18 - Prob. 17PCh. 18 - Distinguishing the Mechanisms of Class I and Class...Ch. 18 - Prob. 19PCh. 18 - Understanding the Mechanism of Hemolytic Anemia...Ch. 18 - Prob. 21PCh. 18 - Based on your residing of this chapter, what would...Ch. 18 - Examine the ActiveModel for alcohol dehydrogenase...Ch. 18 - Based on your knowledge of the structure of NAD+...Ch. 18 - Using the ActiveModel for phosphofructokinase...
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- Sodium borohydride (NaBH4) is a potent inhibitor of aldolase. It is known to ONLY inhibit theenzyme when it is complexed with substrate. Treatment of the enzyme alone has no effect.What is the mechanism for this inhibition?arrow_forwardA non-hydrolysable ATP (AMPPNP - below) is ingested by a graduate student on a dare. Whateffects would you anticipate on his metabolism?arrow_forwardShow the mechanism for the acid-catalyzed formation of an [α-1,6] glycosidic linkagebetween two molecules of α-D-glucopyranose. Please sketch the structure and use arrows showing electron flow!arrow_forward
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