Biochemistry
6th Edition
ISBN: 9781305577206
Author: Reginald H. Garrett, Charles M. Grisham
Publisher: Cengage Learning
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Chapter 18, Problem 21P
Interpretation Introduction
Interpretation:
The correct option regarding the phosphofructokinase should be identified.
Introduction:
Phosphofructokinases are kinase group of enzyme, phosphorylates fructose-6 phosphate by utilizing ATPs.
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Students have asked these similar questions
You are studying the kinetics of a novel competitive inhibitor of ATP-citrate lyase that can be used to prevent obesity. What is likely true about this inhibitor?
(A) This inhibitor lowers the Vmax of ATP-citrate lyase.
(B) The inhibitor likely looks structurally similar to acetyl CoA.
(C) The inhibitor binds to an allosteric region on ATP-citrate lyase and prevents catalysis.
(D) You can distinguish between an uninhibited and inhibited enzyme by comparing the x-intercepts on a Lineweaver-Burk plot.
(E) This inhibitor lowers the KM of ATP-citrate lyase.
Related to this question, you should also be able to:
• explain the function of ATP-citrate lyase and why inhibition would prevent obesity
• interpret Michaelis-Menten & Lineweaver-Burk plots related to this question
• explain the differences between a competitive and non-competitive inhibitor
The following are the negative regulators of phosphofructokinase except
Select one:
a. AMP
+b. H
c. Citrate
d. ATP
The effect of ATP on the allosteric enzyme PFK-1 is shown below. For a given concentration of fructose 6-phosphate, the PFK-1 activity increases with increasing concentrations of ATP, but a point is reached beyond which increasing the concentration of ATP inhibits the enzyme.
(a) Explain how ATP can be both a substrate and an inhibitor of PFK-1. How is the enzyme regulated by ATP?
(b) In what ways is glycolysis regulated by ATP levels?
(c) The inhibition of PFK-1 by ATP is diminished when the ADP concentration is high, as shown in the illustration. How can this observation be explained?
*A graph is included for this question*
Chapter 18 Solutions
Biochemistry
Ch. 18 - Characterizing Glycolysis List the reactions of...Ch. 18 - Radiotracer Labeling of Pyruvate from Glucose...Ch. 18 - Effects of Changing Metabolite Concentrations on...Ch. 18 - Prob. 4PCh. 18 - Prob. 5PCh. 18 - The Reactions and Meehanisms of the Leloir Pathway...Ch. 18 - The Effect of lodoacetic Acid on the...Ch. 18 - Prob. 8PCh. 18 - Comparing Glycolysis Entry Points for Sucrose...Ch. 18 - Prob. 10P
Ch. 18 - Prob. 11PCh. 18 - Prob. 12PCh. 18 - Prob. 13PCh. 18 - Energetic of Fructose-1 ,6-bis P Hydrolysis...Ch. 18 - Prob. 15PCh. 18 - Energetics of the Hexokinase Reaction The...Ch. 18 - Prob. 17PCh. 18 - Distinguishing the Mechanisms of Class I and Class...Ch. 18 - Prob. 19PCh. 18 - Understanding the Mechanism of Hemolytic Anemia...Ch. 18 - Prob. 21PCh. 18 - Based on your residing of this chapter, what would...Ch. 18 - Examine the ActiveModel for alcohol dehydrogenase...Ch. 18 - Based on your knowledge of the structure of NAD+...Ch. 18 - Using the ActiveModel for phosphofructokinase...
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