Biochemistry
6th Edition
ISBN: 9781305577206
Author: Reginald H. Garrett, Charles M. Grisham
Publisher: Cengage Learning
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Textbook Question
Chapter 18, Problem 6P
The Reactions and Meehanisms of the Leloir Pathway Write the reactions that permit galactose to be utilized in glycolysis. Write a suitable mechanism, tor one of these reactions.
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Chapter 18 Solutions
Biochemistry
Ch. 18 - Characterizing Glycolysis List the reactions of...Ch. 18 - Radiotracer Labeling of Pyruvate from Glucose...Ch. 18 - Effects of Changing Metabolite Concentrations on...Ch. 18 - Prob. 4PCh. 18 - Prob. 5PCh. 18 - The Reactions and Meehanisms of the Leloir Pathway...Ch. 18 - The Effect of lodoacetic Acid on the...Ch. 18 - Prob. 8PCh. 18 - Comparing Glycolysis Entry Points for Sucrose...Ch. 18 - Prob. 10P
Ch. 18 - Prob. 11PCh. 18 - Prob. 12PCh. 18 - Prob. 13PCh. 18 - Energetic of Fructose-1 ,6-bis P Hydrolysis...Ch. 18 - Prob. 15PCh. 18 - Energetics of the Hexokinase Reaction The...Ch. 18 - Prob. 17PCh. 18 - Distinguishing the Mechanisms of Class I and Class...Ch. 18 - Prob. 19PCh. 18 - Understanding the Mechanism of Hemolytic Anemia...Ch. 18 - Prob. 21PCh. 18 - Based on your residing of this chapter, what would...Ch. 18 - Examine the ActiveModel for alcohol dehydrogenase...Ch. 18 - Based on your knowledge of the structure of NAD+...Ch. 18 - Using the ActiveModel for phosphofructokinase...
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- In different organisms sucrose can be cleaved either by hydrolysis or by phosphorolysis. Calculate the ATP yield per mole of sucrose metabolized by anaerobic glycolysis starting with (a) hydrolytic cleavage and (b) phosphorolytic cleavage.arrow_forwardThe glycerol 3-phosphate required for the synthesis of glycerophospholipids can be synthesized from a glycolytic intermediate. Propose a reaction sequence for this conversionarrow_forwardTo understand the entire glycolytic pathway better, kindly complete the table.arrow_forward
- Draw the Fischer projection of galactcose and show its catabolism until it releases carbon dioxide via complete oxidation. Use inter-related reactions or pathways, correct names and number of moles of intermediates involved, and the enzymes catalyzing the reactions. Account for all the 6 carbons of thr monosaccharide as they become carbon dioxide by encircling them all throughout the pathway you have writtearrow_forwardBehenate (C22H44O2) can be obtained by chain elongation from palmitate. How many ATP equivalents are produced in the degradation of behenate to eleven acetyl-CoA?arrow_forwardIn Bacillus subtilis, threonine is metabolized by the following sequence of reactions: (a) oxidation; (b) decarboxylation;(c) transamination; and (d) oxidation to produce pyruvate. Outline this sequence of steps, show the structures of thesubstances, use abbreviations for the cofactors, and show any enzyme-bound coenzymes. What type of enzyme bound intermediate is likely for reaction (d)?arrow_forward
- In the first stage of glycolysis, fructose-1,6-bisphosphate iscleaved to form glyceraldehyde-3-phosphate and dihydroxyacetone phosphate. The latter molecule can then be converted to glyceraldehyde-3-phosphate. Illustrate themechanisms whereby these reactions occurarrow_forwardBecause of the position of arsenic in the periodic table, arsenate (AsO43- ) is chemically similar to inorganic phosphate and is used by phosphaterequiring enzymes as an alternative substrate. Organic arsenates are quite unstable, however, and spontaneously hydrolyze. Arsenate is known to inhibit ATP production in glycolysis. Identify the target enzyme, and explain the mechanism of inhibition.arrow_forwardcreate a detailed flow chart or diagram that will illustrate all the important features of the glycolytic pathway. I want you to place in your flow chart or diagram the following important information like: 1. the reactants and products of each step, 2. enzymes involved in each step, 3. important by-products generated in some steps, 4. type of the reaction of each step, 5. and the outline of the two stages of the pathway. Also, discuss briefly (4 sentences) how Galactose and Fructose enter the glycolytic pathway.arrow_forward
- Using the Krebs cycle explain oxidative decarboxylation.arrow_forwardLactate can be converted into pyruvate by the enzyme lactate dehydrogenase and the coenzyme NAD+. Write the reaction in the standard biochemical format, using a curved arrow to show the involvement of NAD+.arrow_forwardOrder the cofactors based on their use in the mechanism of the a-etogluterate dehydrogenase complex. 1. Stabilizes a carbanion due to decarboxylation 2. Allows for the splitting of the carbon skeleton from the electron pair generated in a redox reaction 3. Enzyme bond electron carrier that is part of dihydrolipoyl dehydrogenase 4. Final electron acceptor in the overall reaction catalyzed by this complex 1 2 3 4 answer choices: lipoamide, biotin, 2 Fe - 2S cluster, TPP, NAD+, FADarrow_forward
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