Sodium borohydride (NaBH4) is a potent inhibitor of aldolase. It is known to ONLY inhibit theenzyme when it is complexed with substrate. Treatment of the enzyme alone has no effect.What is the mechanism for this inhibition?

Sodium borohydride (NaBH4) is a potent inhibitor of aldolase. It is known to ONLY inhibit theenzyme when it is complexed with substrate. Treatment of the enzyme alone has no effect.What is the mechanism for this inhibition?

Biochemistry

6th Edition

ISBN:9781305577206

Author:Reginald H. Garrett, Charles M. Grisham

Publisher:Reginald H. Garrett, Charles M. Grisham

Chapter26: Synthesis And Degradation Of Nucleotides

Section: Chapter Questions

Problem 11P: The Catabolism of Uric Acid Write a balanced equation for the oxidation of uric acid to glyoxylic...

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Question

Sodium borohydride (NaBH4) is a potent inhibitor of aldolase. It is known to ONLY inhibit the
enzyme when it is complexed with substrate. Treatment of the enzyme alone has no effect.
What is the mechanism for this inhibition?

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