Human Physiology: From Cells to Systems (MindTap Course List)
9th Edition
ISBN: 9781285866932
Author: Lauralee Sherwood
Publisher: Cengage Learning
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Textbook Question
Chapter 4.6, Problem 2CYU
Discuss the roles of phospholipase
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
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2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Chapter 4 Solutions
Human Physiology: From Cells to Systems (MindTap Course List)
Ch. 4.1 - Name the two types of excitable tissue.Ch. 4.1 - Prob. 2CYUCh. 4.1 - State the factor responsible for triggering gate...Ch. 4.2 - Prob. 1CYUCh. 4.2 - Prob. 2CYUCh. 4.2 - Prob. 3CYUCh. 4.3 - Draw and label an action potential, indicating the...Ch. 4.3 - Prob. 2CYUCh. 4.3 - Prob. 3CYUCh. 4.3 - Prob. 4CYU
Ch. 4.4 - Explain why synapses operate only in the direction...Ch. 4.4 - Prob. 2CYUCh. 4.4 - Prob. 3CYUCh. 4.4 - Prob. 4CYUCh. 4.5 - Define target cell.Ch. 4.5 - Distinguish among the four types of extracellular...Ch. 4.5 - Outline the three general means by which binding...Ch. 4.5 - Prob. 4CYUCh. 4.6 - Distinguish between cytokines and eicosanoids.Ch. 4.6 - Discuss the roles of phospholipase A2,...Ch. 4.6 - Prob. 3CYUCh. 4.7 - Prob. 1CYUCh. 4.7 - Prob. 2CYUCh. 4.7 - Prob. 3CYUCh. 4.8 - Prob. 1CYUCh. 4.8 - Prob. 2CYUCh. 4 - Conformational changes in channel proteins brought...Ch. 4 - Prob. 2RECh. 4 - Prob. 3RECh. 4 - Prob. 4RECh. 4 - Second-messenger systems ultimately bring about...Ch. 4 - Each steroidogenic organ has all the enzymes...Ch. 4 - Prob. 7RECh. 4 - Prob. 8RECh. 4 - Prob. 9RECh. 4 - Prob. 10RECh. 4 - Prob. 11RECh. 4 - Prob. 12RECh. 4 - Prob. 13RECh. 4 - A common membrane-bound intermediary between the...Ch. 4 - Prob. 15RECh. 4 - Prob. 16RECh. 4 - Prob. 17RECh. 4 - Prob. 18RECh. 4 - Define the following terms: polarization,...Ch. 4 - Prob. 2UCCh. 4 - Prob. 3UCCh. 4 - Prob. 4UCCh. 4 - Compare the four kinds of gated channels in terms...Ch. 4 - Prob. 6UCCh. 4 - Prob. 7UCCh. 4 - Prob. 8UCCh. 4 - Prob. 9UCCh. 4 - Define signal transduction.Ch. 4 - Compare the tyrosine kinase and JAK/STAT pathways.Ch. 4 - Prob. 12UCCh. 4 - Prob. 13UCCh. 4 - Describe how arachidonic acid is converted into...Ch. 4 - Prob. 15UCCh. 4 - Prob. 16UCCh. 4 - Explain how the cascading effect of hormonal...Ch. 4 - Prob. 18UCCh. 4 - Answer the following questions regarding...Ch. 4 - Prob. 2SQECh. 4 - Prob. 3SQECh. 4 - Prob. 1ACRCh. 4 - The rate at which the Na+K+ pump operates is not...Ch. 4 - Which of the following would occur if a neuron...Ch. 4 - Prob. 3TAHLCh. 4 - Assume presynaptic excitatory neuron A terminates...Ch. 4 - Prob. 5TAHL
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