Human Physiology: From Cells to Systems (MindTap Course List)
9th Edition
ISBN: 9781285866932
Author: Lauralee Sherwood
Publisher: Cengage Learning
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Question
Chapter 4, Problem 2RE
Summary Introduction
To Determine:
If the given statement 'the sodium-potassium pump re-establishes the membrane to resting potential after it has reached the highest point of an action potential' is true or false should be determined.
Introduction:
An action potential can be defined as a quick rise and a subsequent decrease in voltage or membrane potential through a cellular membrane with a distinguishing pattern. Synapse is a junction present between the two neurons.
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Describe the action potential in terms of the different functional states of the voltage- gated Na+ membrane channels (Note: there are three states)
At the peak of the action potential, Vm is approximately -65 mV. Assuming normal intracellular and extracellular K+ concentrations (refer to the table),
(1) calculate the driving force (in mV) that acts on K+ ions
and
(2) use the information obtained in part 1 to determine the direction in which K+ ions will flow (i.e., into the cell or out of cell)
The rising phase of the action potential is the direct result
of the:
O inflow of potassium
O inflow of sodium
O inflow of sodium and potassium
O outflow of sodium
O outflow of sodium and potassium
Chapter 4 Solutions
Human Physiology: From Cells to Systems (MindTap Course List)
Ch. 4.1 - Name the two types of excitable tissue.Ch. 4.1 - Prob. 2CYUCh. 4.1 - State the factor responsible for triggering gate...Ch. 4.2 - Prob. 1CYUCh. 4.2 - Prob. 2CYUCh. 4.2 - Prob. 3CYUCh. 4.3 - Draw and label an action potential, indicating the...Ch. 4.3 - Prob. 2CYUCh. 4.3 - Prob. 3CYUCh. 4.3 - Prob. 4CYU
Ch. 4.4 - Explain why synapses operate only in the direction...Ch. 4.4 - Prob. 2CYUCh. 4.4 - Prob. 3CYUCh. 4.4 - Prob. 4CYUCh. 4.5 - Define target cell.Ch. 4.5 - Distinguish among the four types of extracellular...Ch. 4.5 - Outline the three general means by which binding...Ch. 4.5 - Prob. 4CYUCh. 4.6 - Distinguish between cytokines and eicosanoids.Ch. 4.6 - Discuss the roles of phospholipase A2,...Ch. 4.6 - Prob. 3CYUCh. 4.7 - Prob. 1CYUCh. 4.7 - Prob. 2CYUCh. 4.7 - Prob. 3CYUCh. 4.8 - Prob. 1CYUCh. 4.8 - Prob. 2CYUCh. 4 - Conformational changes in channel proteins brought...Ch. 4 - Prob. 2RECh. 4 - Prob. 3RECh. 4 - Prob. 4RECh. 4 - Second-messenger systems ultimately bring about...Ch. 4 - Each steroidogenic organ has all the enzymes...Ch. 4 - Prob. 7RECh. 4 - Prob. 8RECh. 4 - Prob. 9RECh. 4 - Prob. 10RECh. 4 - Prob. 11RECh. 4 - Prob. 12RECh. 4 - Prob. 13RECh. 4 - A common membrane-bound intermediary between the...Ch. 4 - Prob. 15RECh. 4 - Prob. 16RECh. 4 - Prob. 17RECh. 4 - Prob. 18RECh. 4 - Define the following terms: polarization,...Ch. 4 - Prob. 2UCCh. 4 - Prob. 3UCCh. 4 - Prob. 4UCCh. 4 - Compare the four kinds of gated channels in terms...Ch. 4 - Prob. 6UCCh. 4 - Prob. 7UCCh. 4 - Prob. 8UCCh. 4 - Prob. 9UCCh. 4 - Define signal transduction.Ch. 4 - Compare the tyrosine kinase and JAK/STAT pathways.Ch. 4 - Prob. 12UCCh. 4 - Prob. 13UCCh. 4 - Describe how arachidonic acid is converted into...Ch. 4 - Prob. 15UCCh. 4 - Prob. 16UCCh. 4 - Explain how the cascading effect of hormonal...Ch. 4 - Prob. 18UCCh. 4 - Answer the following questions regarding...Ch. 4 - Prob. 2SQECh. 4 - Prob. 3SQECh. 4 - Prob. 1ACRCh. 4 - The rate at which the Na+K+ pump operates is not...Ch. 4 - Which of the following would occur if a neuron...Ch. 4 - Prob. 3TAHLCh. 4 - Assume presynaptic excitatory neuron A terminates...Ch. 4 - Prob. 5TAHL
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- Conformational changes in channel proteins brought about by voltage changes are responsible for opening and closing Na+ and K+ gates during the generation of an action potential. (True or false?)arrow_forwardDraw and label an action potential, indicating the ion movements responsible for the rising phase and the falling phase.arrow_forwardDefine an action potential.arrow_forward
- The accelerating flow of _______ ions through gated channels across the membrane triggers an action potential. a. potassium b. sodium c. hydrogen d. a and barrow_forwardAt the peak of an action potential, would the relative permeability of Na be higher than K? Which ion would be the least permeable to the membrane during falling phase?arrow_forwardA True OUTSIDE CELL This cell is at rest. False INSIDE CELL C D T Earrow_forward
- Draw a typical action potential (correctly label axis) and explain in words the roles of ion channels in generating the different phases of the action potential. (Extra credit: How would opening voltage gated calcium channels upon depolarization affect the shape of the action potential if they have a relatively slow inactivation rate?)arrow_forwardWhat degree of action potential in which the membrane potential moves from its maximum degree of depolarization toward the value of resting membrane potential?arrow_forwardWhat is the relative importance of the Na+/K+ pump in action potential propagation?arrow_forward
- Epilepsy is a condition which results in seizures stemming from excessive or abnormal activity of neurons. This can occur either from hyperexcitability of excitatory neurons, or impairment of inhibitory neurons. That is to say, either the excitatory pathways become overactive, or the inhibitory pathways, designed to temper the excitatory pathways, are not active enough. Much of the research done on epilepsy focuses on voltage-gated sodium channels, and to date over 700 different mutations to the channel have been identified as playing a role in epilepsy. The means by which these mutations contribute to epilepsy is quite complex, but for the sake of this CAL, let's simplify and apply what we have learned so far to identify potential mechanisms for this condition. In what way could voltage-gated sodium channels be affected in excitatory neurons which would increase the likelihood of the neuron firing an action potential? (one correct answer) The inactivation gate is slower to close. The…arrow_forwardWhat will happen if threshold value for the generation of action potential is not reached?arrow_forwarddendrotoxins, produced by the mamba snakes are inhibitors of the voltage gated k+ channel. what phase of the action potential with this toxin effect? how would it affect ion permeability during this phase howard ion movement be affected?arrow_forward
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