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2. Which of the following mutant proteins is expected to have a dominant negative effect when over- expressed in normal cells? a. mutant P13-kinase that lacks the SH2 domain but retains the kinase function b. mutant Grb2 protein that cannot bind to RTK c. mutant RTK that lacks the extracellular domain d. mutant PDK that has the PH domain but lost the kinase function e. all of the above

2. Which of the following mutant proteins is expected to have a dominant negative effect when over- expressed in normal cells? a. mutant P13-kinase that lacks the SH2 domain but retains the kinase function b. mutant Grb2 protein that cannot bind to RTK c. mutant RTK that lacks the extracellular domain d. mutant PDK that has the PH domain but lost the kinase function e. all of the above

Biology: The Dynamic Science (MindTap Course List)
Biology: The Dynamic Science (MindTap Course List)
4th Edition
ISBN:9781305389892
Author:Peter J. Russell, Paul E. Hertz, Beverly McMillan
Publisher:Peter J. Russell, Paul E. Hertz, Beverly McMillan
Chapter9: Cell Communication
Section: Chapter Questions
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22. Which of the following mutant proteins is expected to have a dominant negative effect when over-

 

expressed in normal cells?

 

a. mutant PI3-kinase that lacks the SH2 domain but retains the kinase function

 

b. mutant Grb2 protein that cannot bind to RTK

 

c. mutant RTK that lacks the extracellular domain

 

d. mutant PDK that has the PH domain but lost the kinase function

 

e. all of the above

2. Which of the following mutant proteins is expected to have a dominant negative effect when over- expressed in normal cells? a. mutant P13-kinase that lacks the SH2 domain but retains the kinase function b. mutant Grb2 protein that cannot bind to RTK c. mutant RTK that lacks the extracellular domain d. mutant PDK that has the PH domain but lost the kinase function e. all of the above
Transcribed Image Text:2. Which of the following mutant proteins is expected to have a dominant negative effect when over- expressed in normal cells? a. mutant P13-kinase that lacks the SH2 domain but retains the kinase function b. mutant Grb2 protein that cannot bind to RTK c. mutant RTK that lacks the extracellular domain d. mutant PDK that has the PH domain but lost the kinase function e. all of the above
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