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5. Flecainide is a medication used to prevent and treat abnormally fast heart rates but can cause death when administered at high doses in highly sensitive individuals. The standard margin of safety would be influenced most significantly by which of the following features of the quantal dose-response curve? a) The ED50 and TD50 b) The ED50 and LD50 c) Flecainide's intrinsic activity d) The no observable effect level (NOEL) e) The slope of the therapeutic and lethal response curves

5. Flecainide is a medication used to prevent and treat abnormally fast heart rates but can cause death when administered at high doses in highly sensitive individuals. The standard margin of safety would be influenced most significantly by which of the following features of the quantal dose-response curve? a) The ED50 and TD50 b) The ED50 and LD50 c) Flecainide's intrinsic activity d) The no observable effect level (NOEL) e) The slope of the therapeutic and lethal response curves

Essentials of Pharmacology for Health Professions
Essentials of Pharmacology for Health Professions
7th Edition
ISBN:9781305441620
Author:WOODROW
Publisher:WOODROW
Chapter25: Cardiovascular Drugs
Section: Chapter Questions
Problem 25CRQ
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5. Flecainide is a medication used to prevent and treat abnormally fast heart rates but can cause death when administered at high doses in highly sensitive individuals. The standard margin of safety would be influenced most significantly by which of the following features of the quantal dose-response curve? a) The ED50 and TD50 b) The ED50 and LD50 c) Flecainide's intrinsic activity d) The no observable effect level (NOEL) e) The slope of the therapeutic and lethal response curves
Transcribed Image Text:5. Flecainide is a medication used to prevent and treat abnormally fast heart rates but can cause death when administered at high doses in highly sensitive individuals. The standard margin of safety would be influenced most significantly by which of the following features of the quantal dose-response curve? a) The ED50 and TD50 b) The ED50 and LD50 c) Flecainide's intrinsic activity d) The no observable effect level (NOEL) e) The slope of the therapeutic and lethal response curves
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