Amino acids in solution have standard pka's of side chains that vary slightly depending on the book or source. However, pKa's of side chains in proteins can vary. See the table below. Group model range in proteins Histidine (Imidizole) 6.4 (6.0) 58 Tyrosine (OH) 9.7 (10.1) 912 Cysteine (SH) 9.1 (10.3) 811 Data from Enzyme Structure and Function by Fersht. () = (obtained on small peptides) 6. If you obtained a peptide that had 4 adjacent lysine residues do you think that the pK's of the lysines side chains would increase, decrease or stay the same as compared to the standard pK (in table)? Explain your reasoning. 7. If you obtained a peptide that had 4 adjacent glutamic acid residues do you think that the pK's of the glutamic acid side chains would increase, decrease or stay the same as compared to the standard pk (in table)? Explain your reasoning.

Biochemistry
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ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
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Chapter1: Biochemistry: An Evolving Science
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Amino acids in solution have standard pka's of side chains that vary slightly depending on the book or
source. However, pKa's of side chains in proteins can vary. See the table below.
Group
model
range in proteins
Histidine (Imidizole)
6.4 (6.0)
58
Tyrosine (OH)
9.7 (10.1)
912
Cysteine (SH)
9.1 (10.3)
811
Data from Enzyme Structure and Function by Fersht. () = (obtained on small peptides)
6. If you obtained a peptide that had 4 adjacent lysine residues do you think that the pK's of the lysines
side chains would increase, decrease or stay the same as compared to the standard pK (in table)?
Explain your reasoning.
7. If you obtained a peptide that had 4 adjacent glutamic acid residues do you think that the pK's of the
glutamic acid side chains would increase, decrease or stay the same as compared to the standard pk (in
table)? Explain your reasoning.
Transcribed Image Text:Amino acids in solution have standard pka's of side chains that vary slightly depending on the book or source. However, pKa's of side chains in proteins can vary. See the table below. Group model range in proteins Histidine (Imidizole) 6.4 (6.0) 58 Tyrosine (OH) 9.7 (10.1) 912 Cysteine (SH) 9.1 (10.3) 811 Data from Enzyme Structure and Function by Fersht. () = (obtained on small peptides) 6. If you obtained a peptide that had 4 adjacent lysine residues do you think that the pK's of the lysines side chains would increase, decrease or stay the same as compared to the standard pK (in table)? Explain your reasoning. 7. If you obtained a peptide that had 4 adjacent glutamic acid residues do you think that the pK's of the glutamic acid side chains would increase, decrease or stay the same as compared to the standard pk (in table)? Explain your reasoning.
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