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VI. Unifying themes of major receptor superfamilies: Provide and explain 2 examples of each of the following processes, making reference to ion channels, G-coupled protein receptors, tyrosine kinase receptors and/or nuclear receptors. You can provide examples from different receptors types for different processes a) How binding of an agonist to its receptor initiates a pharmacodynamic response at the receptor-ligand level (biochemical/molecular level). b) How receptor activation initiates intracellular signaling pathways and/or effector molecules (cellular mechanism). c) How receptors and/or receptor-mediated signaling are down-regulated following continued activation by an endogenous or xenobiotic agonist (desensitization). d) How different types of receptors within the same family can, despite a high degree of homology and shared functionality, generate distinct pharmacodynamic effects (i.e. modulate different signaling pathways in different ways or in different cells/tissues).

VI. Unifying themes of major receptor superfamilies: Provide and explain 2 examples of each of the following processes, making reference to ion channels, G-coupled protein receptors, tyrosine kinase receptors and/or nuclear receptors. You can provide examples from different receptors types for different processes a) How binding of an agonist to its receptor initiates a pharmacodynamic response at the receptor-ligand level (biochemical/molecular level). b) How receptor activation initiates intracellular signaling pathways and/or effector molecules (cellular mechanism). c) How receptors and/or receptor-mediated signaling are down-regulated following continued activation by an endogenous or xenobiotic agonist (desensitization). d) How different types of receptors within the same family can, despite a high degree of homology and shared functionality, generate distinct pharmacodynamic effects (i.e. modulate different signaling pathways in different ways or in different cells/tissues).

Biology: The Dynamic Science (MindTap Course List)
Biology: The Dynamic Science (MindTap Course List)
4th Edition
ISBN:9781305389892
Author:Peter J. Russell, Paul E. Hertz, Beverly McMillan
Publisher:Peter J. Russell, Paul E. Hertz, Beverly McMillan
Chapter9: Cell Communication
Section: Chapter Questions
Problem 11TYK: Discuss Concepts Describe the possible ways in which a G-proteincoupled receptor pathway could...
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VI. Unifying themes of major receptor superfamilies: Provide and explain 2 examples of each of the following processes, making reference to ion channels, G-coupled protein receptors, tyrosine kinase receptors and/or nuclear receptors. You can provide examples from different receptors types for different processes a) How binding of an agonist to its receptor initiates a pharmacodynamic response at the receptor-ligand level (biochemical/molecular level). b) How receptor activation initiates intracellular signaling pathways and/or effector molecules (cellular mechanism).
Transcribed Image Text:VI. Unifying themes of major receptor superfamilies: Provide and explain 2 examples of each of the following processes, making reference to ion channels, G-coupled protein receptors, tyrosine kinase receptors and/or nuclear receptors. You can provide examples from different receptors types for different processes a) How binding of an agonist to its receptor initiates a pharmacodynamic response at the receptor-ligand level (biochemical/molecular level). b) How receptor activation initiates intracellular signaling pathways and/or effector molecules (cellular mechanism).
c) How receptors and/or receptor-mediated signaling are down-regulated following continued activation by an endogenous or xenobiotic agonist (desensitization). d) How different types of receptors within the same family can, despite a high degree of homology and shared functionality, generate distinct pharmacodynamic effects (i.e. modulate different signaling pathways in different ways or in different cells/tissues).
Transcribed Image Text:c) How receptors and/or receptor-mediated signaling are down-regulated following continued activation by an endogenous or xenobiotic agonist (desensitization). d) How different types of receptors within the same family can, despite a high degree of homology and shared functionality, generate distinct pharmacodynamic effects (i.e. modulate different signaling pathways in different ways or in different cells/tissues).
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