Estimate the values for Vmax and Km.Vmax=μM/minKm=μM A graph of the Michaelis-Menten equation is a plot of a reaction's initial velocity (UO) at different substrate concentrations ([S]).First, move the line labeled Vmax to a position that representsthe maximum velocity of the enzyme.Next, move the line labeled 1/2 Vmax to its correct position.Then, move the line labeled Km to its correct position.Estimate the values for V max and Km.1/2 VmaxMichaelis-Menten curve300Vmax275250225200v (μM/min)175150K2 125m1007550250010202050583040506060[S] (μM)7010608090100

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Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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The antibiotic A is administered as a 1.0 g IV-bolus to a 34 years old male subject. The following plasma concentration data were collected: Time (hr) Concentrations (mg/L) 0.2 21.51 0.5 17.18 1 12.26 1.5 8.88 2 6.63 3 4.08 4 2.78 8 1.02 12 0.45 24 0.04 Calculate the following parameters (use Excel and the curve stripping method): PARAMETER VALUE UNITS Elimination half-life (b) Elimination half-life (k10) Distribution rate constant V1 Vss Clearance AUC
Give typed solution only Calculate the ML/HR (rate) Merrem 1 g (1g/50 mL of 0.9% NACL) IVBP Q 12 hours Infuse over 30 minutes. *Please show how you would work this using dimensional analysis, if possible. If not, it's fine if you show how you arrived at your answer another way*
calculate the drop rate of an IV if 1000mL of a 5% glucose solution is to be administered over a period of a 8h and the drop factor is 20 gtt/mL
49 A 1 litre infusion of sodium chloride 0.9% is being given at a rate of 28 drops/min (standard giving set). How long will the infusion run at the specified rate?
A patient receives an intravenous (IV) solution that flows at the rate of 150 mL per hour. How much fluid does the patient receive in 20. min? (Answer = 50 mL) How long does it take for the patient to receive 90. mL of fluid? (Ans. = 0.6 hr or 36 min.) If the IV bag holds 600. mL of fluid, how many minutes does it take to empty the bag? (t = 4 hrs) If the solution contains 90. mg of glucose per mL, how long will it take to give the patient 2.0 g of glucose? (t = 0.15 hr or 9 min)
A 100 ml vial of alteplase, a thrombolytic drug, contains 100 mg of drug equivalent to 58,000,000 international units to be administered via intravenous infusion. Determine the units administered to a patient who weighs 172 lb at a dose of 0.9 mg/kg and the volume of injection to use. 43,100,200 units: 78.60 mL 50,810,000 units: 75.50 mL O45,500,700 units: 73.80 mL 40,808,800 units: 70.40 mL
Calculate the 5 different volumes of BSA needed for the standard curve. Prepare a table showing the volume of BSA and water needed in the cuvette for each concnetration
The biexponential equation for a two compartment model drug is C1,t = 50.0e-1.64t + 20.0e-0.147t. The drug is administered as a rapid IV bolus at t = 0. After 2.00 hours how many mg/l will the drug concentration in the central compartment be.
How does one measure Km using a Lineweaver-Burk plot? 1. By determining the reciprocal of the y-intercept 2. By determining the negative reciprocal of the x-intercept 3. By determining the slope and multiplying it by kcat 4. By determining the saturation point
What term describes kcat/Km? What is the maximum value that this term can attain? Explain.
List the factors that increase and decrease the RVSWI index?
what are the physiological changes you expect if you begin to runat a pace of10km/hr for 5 minutes and a vo2max is 45ml/kg/min?

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