The antibiotic A is administered as a 1.0 g IV-bolus to a 34 years old male subject. The following plasma concentration data were collected: Time(hr)Concentrations (mg/L)0.221.510.517.18112.261.58.8826.6334.0842.7881.02120.45240.04 Calculate the following parameters (use Excel and the curve stripping method): PARAMETERVALUEUNITSElimination half-life (b) Elimination half-life (k10) Distribution rate constant V1 Vss Clearance AUC

Drug elimination refers to the irreversible removal of drugs from the body by all routes of…

Answered: The antibiotic A is administered as a…

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Question

The antibiotic A is administered as a 1.0 g IV-bolus to a 34 years old male subject. The following plasma concentration data were collected:

Calculate the following parameters (use Excel and the curve stripping method):

Expert Solution

Step 1

Drug elimination refers to the irreversible removal of drugs from the body by all routes of elimination.
It is divided into two major components: excretion and biotransformation.
Drug clearance considers the entire body as a single drug-eliminating system from which many unidentified elimination processes may occur.
The elimination rate constant (Ke) is expressed by the following eqution= $K_{e} = \frac{CL}{V_{d}}$
V_d is the volume of distribution of drugs per unit of time.