Biochemistry
6th Edition
ISBN: 9781305577206
Author: Reginald H. Garrett, Charles M. Grisham
Publisher: Cengage Learning
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Textbook Question
Chapter 17, Problem 12P
How Do Vitamin-Derived Coenzymes Aid
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The following diagram shows the biosynthesis of B12 coenzymes, starting
with the vitamin. DMB is dimethylbenzimidazole.
CH,
OH
OH
- DMB
2e
(8
Coa+
он он
A
-DMB
DMB
CH,
Åderine
АТР
P + PP,
-DMB
(a) What one additional substrate or cofactor is required by enzyme B?
(b) Genetic deficiency in animals of enzyme Cwould result in excessive
urinary excretion of what compound?
(c) Some forms of the condition described in (b) can be successfully treated
by injection of rather massive doses of vitamin B12. What kind of genetic
alteration in the enzyme would be consistent with this result?
(d) Genetic deficiency in animals of ezyme B will result in excessive uri-
nary excretion ofwhat amino acid?
What is the first step in the catabolism of an amino acid to intermediates of cellular respiration?
Does PFK-2 (Phosphofructokinase-2) have coenzymes and Allosteric reguation?
Chapter 17 Solutions
Biochemistry
Ch. 17 - Global Carbon Dioxide Cycling Expressed as Human...Ch. 17 - Prob. 2PCh. 17 - Where Do the O Atoms in Organisms Come From? Name...Ch. 17 - How Do Catabolism and Anabolism Differ? What are...Ch. 17 - How Art the Enzymes of Metabolic Pathways...Ch. 17 - Why Do Anabolic and Catabolic Pathways Differ? Why...Ch. 17 - Prob. 7PCh. 17 - How Is Metabolism Regulated? (Integrates with...Ch. 17 - Prob. 9PCh. 17 - Prob. 10P
Ch. 17 - Which Is “Better: NMR or MS? Compare and...Ch. 17 - How Do Vitamin-Derived Coenzymes Aid Metabolism?...Ch. 17 - What Art the Features of the Series of -omes?...Ch. 17 - Prob. 14PCh. 17 - Prob. 15PCh. 17 - Prob. 16PCh. 17 - Prob. 17PCh. 17 - Prob. 18PCh. 17 - Which of the following experimental approaches is...Ch. 17 - Prob. 20P
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- How many acetyl CoA molecules are produced in one cycle of beta oxidation? How many cycles would it take to catabolize a stearic acid molecule (a fatty acid, [18:0]) into acetyl Co A units? a)How many acetyl CoA molecules would be produced? b) How many reduced nucleotides would be produced? c) If a molecule of glucose produces a net 32 ATP when completely catabolized, which do you think will produce more energy, one molecule of glucose or one molecule of stearic acid? Justify your answer.arrow_forwardHow many NTP molecules are required for the synthesis of one molecule of glucose from two molecules of pyruvate? How many NADH molecules?arrow_forwardThe following diagram shows reaction curves for aspartate transcarbamoylase (ATCase) with carbamoylphosphate and different concentrations of aspartate, in the absence of ATP (curve 1) and presence of ATP (curve 2). What do the shapes of the curves tell us about the ATCase enzyme? 2 جر [aspartate] It binds substrate through a sequential mechanism. It binds substte cooperatively. It obeys Michaelis-Menten kinetics. It binds substrate through a concerted mechanism.arrow_forward
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