Biochemistry
6th Edition
ISBN: 9781305577206
Author: Reginald H. Garrett, Charles M. Grisham
Publisher: Cengage Learning
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Textbook Question
Chapter 17, Problem 12P
How Do Vitamin-Derived Coenzymes Aid
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The following diagram shows the biosynthesis of B12 coenzymes, starting
with the vitamin. DMB is dimethylbenzimidazole.
CH,
OH
OH
- DMB
2e
(8
Coa+
он он
A
-DMB
DMB
CH,
Åderine
АТР
P + PP,
-DMB
(a) What one additional substrate or cofactor is required by enzyme B?
(b) Genetic deficiency in animals of enzyme Cwould result in excessive
urinary excretion of what compound?
(c) Some forms of the condition described in (b) can be successfully treated
by injection of rather massive doses of vitamin B12. What kind of genetic
alteration in the enzyme would be consistent with this result?
(d) Genetic deficiency in animals of ezyme B will result in excessive uri-
nary excretion ofwhat amino acid?
What is the first step in the catabolism of an amino acid to intermediates of cellular respiration?
What are the products of glycolysis (from one glucose molecule)? What happens with NADH under aero (with oxygen) vs anaerobic (without oxygen)?
Chapter 17 Solutions
Biochemistry
Ch. 17 - Global Carbon Dioxide Cycling Expressed as Human...Ch. 17 - Prob. 2PCh. 17 - Where Do the O Atoms in Organisms Come From? Name...Ch. 17 - How Do Catabolism and Anabolism Differ? What are...Ch. 17 - How Art the Enzymes of Metabolic Pathways...Ch. 17 - Why Do Anabolic and Catabolic Pathways Differ? Why...Ch. 17 - Prob. 7PCh. 17 - How Is Metabolism Regulated? (Integrates with...Ch. 17 - Prob. 9PCh. 17 - Prob. 10P
Ch. 17 - Which Is “Better: NMR or MS? Compare and...Ch. 17 - How Do Vitamin-Derived Coenzymes Aid Metabolism?...Ch. 17 - What Art the Features of the Series of -omes?...Ch. 17 - Prob. 14PCh. 17 - Prob. 15PCh. 17 - Prob. 16PCh. 17 - Prob. 17PCh. 17 - Prob. 18PCh. 17 - Which of the following experimental approaches is...Ch. 17 - Prob. 20P
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- Figure 27.3 illustrates the response of R (ATP-regenerating) and U (ATP-utilizing) enzymes to energy charge. a. Would hexokinase be an R enzyme or a U enzyme? Would glutamine: PRPP amidotransferase, the second enzyme in purine biosynthesis, be an R enzyme or a U enzyme? b. If energy charge = 0.5: Is the activity of hexokinase high or low? Is ribose-5-P pyrophosphokinase activity high or low? c. If energy charge = 0.95: Is the activity of hexokinase high or low? Is ribose-5-P pyrophosphokinase activity high or low?arrow_forwardHow Do Catabolism and Anabolism Differ? What are the features that generally distinguish pathways of catabolism from pathways of anabolism?arrow_forwardWhich of the following is the correct account for acetyl CoA, NADH , and FADH2 for the beta-oxidation of stearic acid (saturated fatty acid with 18 carbon atoms)? -9;8;5 -9;8;8 -18;9;9 -18;18;18 -9;9;9arrow_forward
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- What does the term “oxidative phosphorylation” mean? What is substrate-level phosphorylation? Are these processes the same? Explain.arrow_forwardHow many acetyl CoA molecules are produced in one cycle of beta oxidation? How many cycles would it take to catabolize a stearic acid molecule (a fatty acid, [18:0]) into acetyl Co A units? a)How many acetyl CoA molecules would be produced? b) How many reduced nucleotides would be produced? c) If a molecule of glucose produces a net 32 ATP when completely catabolized, which do you think will produce more energy, one molecule of glucose or one molecule of stearic acid? Justify your answer.arrow_forwardHow many NTP molecules are required for the synthesis of one molecule of glucose from two molecules of pyruvate? How many NADH molecules?arrow_forward
- Please helparrow_forwardWhich of the following statements about de novo purine synthesis is true? (A) Purine nucleotides are formed by separately synthesizing the phosphorylated ribose and the purine ring and then joining them together.(B) GMP is formed first and is used as a precursor to form AMP.(C) The synthesis of AMP from inosinate is driven forward by ATP hydrolysis. (D) GMP synthetase uses NADPH and glutamine to modify the inosinate ring to form GMP.(E) Replacement of the C-1 PPi on PRPP with an amine is required to construct the purine ring on the ribose sugar.arrow_forwardDescribe how a) Mean Arterial Pressure, b) Maximal Oxygen Consumption, and c) Blood Flow are determined using its formula. In addition, you should explain what those factors are including cardiac output, stroke volume, heart rate, resistance, a-vO2 difference, etc. Describe how many ATPs can be generated by complete cycles of beta oxidation of free fatty acid with 20 carbons. You should indicate how many cycles of beta oxidation and Krebs cycle, and total number of products as wellarrow_forward
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