6. Suppose that brown is the wild-type colour of the iris of eyes. However, dominant autosomal mutations in the genes coding the proteins responsible for the steps of colour determination (shown below) negatively disrupts their functions. The colour of the iris can be either blue, green, brown or no coloration (results in pink iris). B gene represents the pigment transporter; L gene represents the luciferase enzyme; and the C gene represents tyrosinase enzyme). The biochemical pathway for colour determination is the following: Cell of the human iris Blue Blue Luciferase (L) Green Pigment transporter (B) Tyrosinase (C) Brown a. Assuming no confounding factors, which genotype (include all genes mentioned) will result in green iris? b. Assuming that the transporter is composed of 4 subunits of protein coded by the same gene. What will the colour of the iris be if an individual is heterozygote for the gene expressing the transporter? c. Now, assuming the tyrosinase step is incompletely dominant and all the other steps are functional (homozygote recessive for step B and L), what will be the colour of the iris of the eyes?
6. Suppose that brown is the wild-type colour of the iris of eyes. However, dominant autosomal mutations in the genes coding the proteins responsible for the steps of colour determination (shown below) negatively disrupts their functions. The colour of the iris can be either blue, green, brown or no coloration (results in pink iris). B gene represents the pigment transporter; L gene represents the luciferase enzyme; and the C gene represents tyrosinase enzyme). The biochemical pathway for colour determination is the following: Cell of the human iris Blue Blue Luciferase (L) Green Pigment transporter (B) Tyrosinase (C) Brown a. Assuming no confounding factors, which genotype (include all genes mentioned) will result in green iris? b. Assuming that the transporter is composed of 4 subunits of protein coded by the same gene. What will the colour of the iris be if an individual is heterozygote for the gene expressing the transporter? c. Now, assuming the tyrosinase step is incompletely dominant and all the other steps are functional (homozygote recessive for step B and L), what will be the colour of the iris of the eyes?
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Transcribed Image Text:6. Suppose that brown is the wild-type colour of the iris of eyes. However, dominant
autosomal mutations in the genes coding the proteins responsible for the steps of colour
determination (shown below) negatively disrupts their functions. The colour of the iris can
be either blue, green, brown or no coloration (results in pink iris). B gene represents the
pigment transporter; L gene represents the luciferase enzyme; and the C gene represents
tyrosinase enzyme).
The biochemical pathway for colour determination is the following:
Cell of the human iris
Blue
Blue
Luciferase
(L)
Green
Pigment
Tyrosinase
(C)
transporter
(B)
Brown
a. Assuming no confounding factors, which genotype (include all genes mentioned) will
result in green iris?
b. Assuming that the transporter is composed of 4 subunits of protein coded by the same
gene. What will the colour of the iris be if an individual is heterozygote for the gene
expressing the transporter?
c. Now, assuming the tyrosinase step is incompletely dominant and all the other steps are
functional (homozygote recessive for step B and L), what will be the colour of the iris
of the eyes?
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