A chromatin rearrangement on the EGFR gene promoter An mRNA stabilising protein binding to the 3' untranslated region Increased degradation of the EGFR receptor protein by the proteasome Increased recruitment of RNA polymerase to the EGFR gene A translational control element in an intron of the EGFR gene Sequences controlling the ribosome recruitment to the 5' UTR of the EGFR encoding mRNA enhance its translation

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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9. In some neuronal tumours, the protein levels of the EGF receptor are elevated, but mRNA levels are unchanged. Which of these regulatory events is most likely
responsible?
A chromatin rearrangement on the EGFR gene promoter
An mRNA stabilising protein binding to the 3' untranslated region
Increased degradation of the EGFR receptor protein by the proteasome
Increased recruitment of RNA polymerase to the EGFR gene
A translational control element in an intron of the EGFR gene
Sequences controlling the ribosome recruitment to the 5' UTR of the EGFR encoding mRNA enhance its translation
Transcribed Image Text:9. In some neuronal tumours, the protein levels of the EGF receptor are elevated, but mRNA levels are unchanged. Which of these regulatory events is most likely responsible? A chromatin rearrangement on the EGFR gene promoter An mRNA stabilising protein binding to the 3' untranslated region Increased degradation of the EGFR receptor protein by the proteasome Increased recruitment of RNA polymerase to the EGFR gene A translational control element in an intron of the EGFR gene Sequences controlling the ribosome recruitment to the 5' UTR of the EGFR encoding mRNA enhance its translation
8. Below is a diagram of the MYC gene, match the arrows with the correct description.
127.73M
Genes
(Comprehensive set...
MYC-201
protein coding
-
MYC-209
protein coding
DO
MYC-203>
protein coding
0-
protein coding 2
-
MYC-208>
protein coding
O
MYC-202
protein coding
O
MYC-205>
protein coding
MYC-207>
protein coding
D
0
MYC-204
processed transcript
1
MYC-211>
protein coding
←
MYC-206>
protein coding
2
i. Arrow 1 is pointing at
ii. Arrow 2 is pointing at
A. polyadenylation site
B. 3' untranslated region
C. transcription start site
D. intron
-27-52 kb
127.74M
-
MYC-212 >
arotein codina
E. 5' untranslated region
F. promoter region
G. transcription stop site
H. protein coding region
127.73
Transcribed Image Text:8. Below is a diagram of the MYC gene, match the arrows with the correct description. 127.73M Genes (Comprehensive set... MYC-201 protein coding - MYC-209 protein coding DO MYC-203> protein coding 0- protein coding 2 - MYC-208> protein coding O MYC-202 protein coding O MYC-205> protein coding MYC-207> protein coding D 0 MYC-204 processed transcript 1 MYC-211> protein coding ← MYC-206> protein coding 2 i. Arrow 1 is pointing at ii. Arrow 2 is pointing at A. polyadenylation site B. 3' untranslated region C. transcription start site D. intron -27-52 kb 127.74M - MYC-212 > arotein codina E. 5' untranslated region F. promoter region G. transcription stop site H. protein coding region 127.73
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