eproduce and spend their lives collecting food, tending the queen, and raising her offspring. ertain female bees become queens due to consumption of royal jelly, which silences the xpression of a gene encoding a DNA methyltransferase, Dnmt3 (this means that it's function is to dd methyl groups to DNA). Thus, queen vs. worker bee fate is regulated epigenetically. Is Dnmt3 an epigenetic writer or eraser enzyme? . Do you predict that Dnmt3 target genes are expressed at higher levels in queens or workers? How would you expect bees to develop (as queens or workers?) if they lack NP95 function (i.e. re homozygous for a loss of function mutation in the bee ortholog of NP95, involved in maintenance of DNA methylation)? Include a description of the impact of royal jelly consumption and your rationale.

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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5). Female honeybees at birth have equal potential to develop as workers or queens. Queens are
much larger than workers, have functional ovaries, and reproduce constantly. Workers don't
reproduce and spend their lives collecting food, tending the queen, and raising her offspring.
Certain female bees become queens due to consumption of royal jelly, which silences the
expression of a gene encoding a DNA methyltransferase, Dnmt3 (this means that it's function is to
add methyl groups to DNA). Thus, queen vs. worker bee fate is regulated epigenetically.
a. Is Dnmt3 an epigenetic writer or eraser enzyme?
b. Do you predict that Dnmt3 target genes are expressed at higher levels in queens or workers?
c. How would you expect bees to develop (as queens or workers?) if they lack NP95 function (i.e.
are homozygous for a loss of function mutation in the bee ortholog of NP95, involved in
maintenance of DNA methylation)? Include a description of the impact of royal jelly consumption
and your rationale.
Transcribed Image Text:5). Female honeybees at birth have equal potential to develop as workers or queens. Queens are much larger than workers, have functional ovaries, and reproduce constantly. Workers don't reproduce and spend their lives collecting food, tending the queen, and raising her offspring. Certain female bees become queens due to consumption of royal jelly, which silences the expression of a gene encoding a DNA methyltransferase, Dnmt3 (this means that it's function is to add methyl groups to DNA). Thus, queen vs. worker bee fate is regulated epigenetically. a. Is Dnmt3 an epigenetic writer or eraser enzyme? b. Do you predict that Dnmt3 target genes are expressed at higher levels in queens or workers? c. How would you expect bees to develop (as queens or workers?) if they lack NP95 function (i.e. are homozygous for a loss of function mutation in the bee ortholog of NP95, involved in maintenance of DNA methylation)? Include a description of the impact of royal jelly consumption and your rationale.
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