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8. Two independent genes are located near each other on the genome of the mouse. Whiskers is required for formation of whiskers, fur is required for fur formation, assume mutations in these genes are recessive (ie require a homozygous to be no-fur, no whiskers) Non-coding region Non-coding region Non-coding region whiskers fiur A E F a) If you insert an extra nucleotide at position B, what will be the phenotype of an animal homozygous for this mutation? (circle one for each: Fur/no fur whiskers/no whiskers ) b) If you insert a nucleotide at position C, what will be the homozygous phenotype? (circle one for each: Fur/no fur whiskers/no whiskers ) c) If you insert a nucleotide at position E, what will be the homozygous phenotype? (circle one for each: Fur/no fur whiskers/no whiskers )

8. Two independent genes are located near each other on the genome of the mouse. Whiskers is required for formation of whiskers, fur is required for fur formation, assume mutations in these genes are recessive (ie require a homozygous to be no-fur, no whiskers) Non-coding region Non-coding region Non-coding region whiskers fiur A E F a) If you insert an extra nucleotide at position B, what will be the phenotype of an animal homozygous for this mutation? (circle one for each: Fur/no fur whiskers/no whiskers ) b) If you insert a nucleotide at position C, what will be the homozygous phenotype? (circle one for each: Fur/no fur whiskers/no whiskers ) c) If you insert a nucleotide at position E, what will be the homozygous phenotype? (circle one for each: Fur/no fur whiskers/no whiskers )

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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### Gene Mutation Analysis in Mice #### Overview: Two independent genes are located near each other on the genome of the mouse. The "whiskers" gene is necessary for whisker formation, and the "fur" gene is essential for fur formation. Mutations in these genes are recessive, meaning they require a homozygous condition to result in the absence of fur or whiskers. #### Diagram Explanation: The diagram shows a linear DNA sequence with the following elements labeled: - **Non-coding regions**: Indicated by lines on either side of the coding regions. - **Whiskers and Fur Genes**: The area representing genetic coding for "whiskers" and "fur." - **Positions A, B, C, D, E, F**: Specific locations on the DNA that are referenced for mutations. #### Questions: **a)** If you insert an extra nucleotide at position **B**, what will be the phenotype of an animal homozygous for this mutation? *(Circle one for each: Fur/no fur, whiskers/no whiskers)* **b)** If you insert a nucleotide at position **C**, what will be the homozygous phenotype? *(Circle one for each: Fur/no fur, whiskers/no whiskers)* **c)** If you insert a nucleotide at position **E**, what will be the homozygous phenotype? *(Circle one for each: Fur/no fur, whiskers/no whiskers)* **d)** If you insert a nucleotide at position **B**, and take one away from position **C**, what will be the homozygous phenotype? *(Circle one for each: Fur/no fur, whiskers/no whiskers)* **e)** If you insert nucleotides at positions **A** and **C**, what will be the homozygous phenotype? *(Circle one for each: Fur/no fur, whiskers/no whiskers)* **f)** If you insert a nucleotide at position **A**, how might you be able to suppress the mutant phenotype? **g)** If you add two nucleotides at position **B**, name two distinct alterations you could make at position **A** that would suppress the phenotype. This exercise helps explore the effects of mutations at specific genetic loci on phenotype expression in organisms.
Transcribed Image Text:### Gene Mutation Analysis in Mice #### Overview: Two independent genes are located near each other on the genome of the mouse. The "whiskers" gene is necessary for whisker formation, and the "fur" gene is essential for fur formation. Mutations in these genes are recessive, meaning they require a homozygous condition to result in the absence of fur or whiskers. #### Diagram Explanation: The diagram shows a linear DNA sequence with the following elements labeled: - **Non-coding regions**: Indicated by lines on either side of the coding regions. - **Whiskers and Fur Genes**: The area representing genetic coding for "whiskers" and "fur." - **Positions A, B, C, D, E, F**: Specific locations on the DNA that are referenced for mutations. #### Questions: **a)** If you insert an extra nucleotide at position **B**, what will be the phenotype of an animal homozygous for this mutation? *(Circle one for each: Fur/no fur, whiskers/no whiskers)* **b)** If you insert a nucleotide at position **C**, what will be the homozygous phenotype? *(Circle one for each: Fur/no fur, whiskers/no whiskers)* **c)** If you insert a nucleotide at position **E**, what will be the homozygous phenotype? *(Circle one for each: Fur/no fur, whiskers/no whiskers)* **d)** If you insert a nucleotide at position **B**, and take one away from position **C**, what will be the homozygous phenotype? *(Circle one for each: Fur/no fur, whiskers/no whiskers)* **e)** If you insert nucleotides at positions **A** and **C**, what will be the homozygous phenotype? *(Circle one for each: Fur/no fur, whiskers/no whiskers)* **f)** If you insert a nucleotide at position **A**, how might you be able to suppress the mutant phenotype? **g)** If you add two nucleotides at position **B**, name two distinct alterations you could make at position **A** that would suppress the phenotype. This exercise helps explore the effects of mutations at specific genetic loci on phenotype expression in organisms.
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