Answered: 8. As explained in the text, the cause…

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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8. As explained in the text, the cause of many genetic
diseases cannot yet be discerned by analyzing wholeexome/genome sequences. But in some of these
seemingly intractable cases, important clues can be
obtained by looking at mRNAs or proteins, rather
than at the DNA.
a. As you will see in more detail in later chapters, it is
possible to use single-molecule methods to sequence cDNA copies of millions of mRNA molecules from any particular tissue cheaply. How
could you sometimes use such information to find
a disease gene? When would this information be
noninformative?
b. A technique called Western blotting allows you to
examine any protein for which you have an antibody; it is possible to see differences in size or
amount of that protein. How could you sometimes
use such information to find a disease gene? When
would this information be noninformative?

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