Two ways to generate double-stranded RNA from a transgene MRNA Transgene Gene Endogenous gene Antisense of transgene FIGURE 8-22 The insertion of a transgene can lead to the production of double-stranded RNA (dsRNA) If the transgene is inserted at the end of a gene in the opposite orientation. The antisense RNA produced when the neighboring gene is transcribed can bind to the MRNA of either the transgene itself or the endogenous gene to produce dsRNA. MRNA of transgene MRNA of endogenous gene OR I u dsRNA dsRNA

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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. In Figure 8-22, show how the double-stranded RNA is
able to silence the transgene. What would have to happen for the transgene to also silence the flanking cellular
gene (in yellow)?

Two ways to generate double-stranded RNA
from a transgene
MRNA
Transgene
Gene
Endogenous
gene
Antisense of
transgene
FIGURE 8-22 The insertion of a transgene can
lead to the production of double-stranded RNA
(dsRNA) If the transgene is inserted at the end of
a gene in the opposite orientation. The antisense
RNA produced when the neighboring gene is
transcribed can bind to the MRNA of either the
transgene itself or the endogenous gene to
produce dsRNA.
MRNA of transgene
MRNA of endogenous gene
OR I u
dsRNA
dsRNA
Transcribed Image Text:Two ways to generate double-stranded RNA from a transgene MRNA Transgene Gene Endogenous gene Antisense of transgene FIGURE 8-22 The insertion of a transgene can lead to the production of double-stranded RNA (dsRNA) If the transgene is inserted at the end of a gene in the opposite orientation. The antisense RNA produced when the neighboring gene is transcribed can bind to the MRNA of either the transgene itself or the endogenous gene to produce dsRNA. MRNA of transgene MRNA of endogenous gene OR I u dsRNA dsRNA
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