2. Chronic myeloid leukemia (CML) is a blood cancer with adult onset. In most CML patients, The Philadelphia Chromosome occurs. This is a chromosomal translocation connecting the Bcr-Abl genes. Bcr-Abl encodes a tyrosine kinase. a. Would the Philadelphia Chromosome translocation be present in all the cells of the CML patient's cells? b. How many times did the Philadelphia Chromosome translocation occur independently in the CML patient? C. Can the patient pass CML to their offspring? Explain your answer. d. Would all cancer cells in this patient have the same gene expression profile?

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