Commonality between molecules in same section should be determined. Concept introduction: Functional groups are groups of atoms present in molecules and are responsible for specific chemical reactions of molecules. It always takes part in chemical reactions. Hydroxyl, carboxyl, amino, carbonyl, phosphate and aldehyde groups are some examples of functional groups.

Question

Doxorubicin, shown here, is an important chemotherapy drug used to treat avariety of cancers, including bladder cancer, breast cancer, and certain forms of leukemia. Doxorubicin works by binding to DNA in such a way that a portion of it penetrates the DNA double helix— a process called intercalation. During transcription— the process that forms RNA— portions of the DNA strands are temporarily separated for the base sequence to be read and then are reconnected. With bound doxorubicin, however, the double helix does not reform properly after the strands are separated, which disrupts replication— the process that forms an identical copy of DNA. Which portion of doxorubicin do you think intercalates into the DNA double helix, and why do you think it has little difficulty doing so?

Answer 1

Question

Chapter 4, Problem 8CTQ

Interpretation Introduction

Interpretation: Commonality between molecules in same section should be determined.

Concept introduction: Functional groups are groups of atoms present in molecules and are responsible for specific chemical reactions of molecules. It always takes part in chemical reactions. Hydroxyl, carboxyl, amino, carbonyl, phosphate and aldehyde groups are some examples of functional groups.

Expert Solution & Answer

Trending nowThis is a popular solution!

See solution

Check out sample textbook solution

Students have asked these similar questions

Doxorubicin, shown here, is an important chemotherapy drug used to treat avariety of cancers, including bladder cancer, breast cancer, and certain forms of leukemia. Doxorubicin works by binding to DNA in such a way that a portion of it penetrates the DNA double helix— a process called intercalation. During transcription— the process that forms RNA— portions of the DNA strands are temporarily separated for the base sequence to be read and then are reconnected. With bound doxorubicin, however, the double helix does not reform properly after the strands are separated, which disrupts replication— the process that forms an identical copy of DNA. Which portion of doxorubicin do you think intercalates into the DNA double helix, and why do you think it has little difficulty doing so?

Select the bonds in the 3D representation of methyl urethane below that are multiple bonds. (Hint: Consider the number of bonds attached to an atom in the image compared to the normal valence of that atom. In a valid structure, the number of bonds to an atom will equal the valence of that atom.) • Gray = C: white = H; red = 0; blue = N; dark green = Cl; brown = Br; light green = F; purple = 1; yellow = S: orange = P. • Double click to select bonds. You can zoom in and out using the mouse scroll wheel (or pinch to zoom on touch screens). ●

The name carbohydrate comes from the fact that many simple sugars have chemical formulae that look like water has simply been added to carbon. (The suffix hydrate from the Greek word hydor ("water") means "compound formed by the addition of water.") The actual chemical structure of carbohydrates doesn't look anything like water molecules bonded to carbon atoms (see sketch at right). But it is nevertheless possible to chemically extract all the hydrogen and oxygen from many simple carbohydrates as water, leaving only carbon behind. If you search the Internet for "reaction of sulfuric acid and sugar" you will find some impressive videos of this. Suppose you had (200. g) of ordinary table sugar, which chemists call sucrose, and which has the chemical formula C12H₂2011. Calculate the maximum mass of water you could theoretically extract. Be sure your answer has alunit symbol, and round it to 3 significant digits. 0 HO CH₂OH OH OH OH The actual chemical structure of glucose.