Chapter 26, Problem 26.66AP

Interpretation Introduction

Interpretation:

For the synthesis of metenkephalin, the mRNA sequence has to be synthesized.

Concept Introduction:

Codon: A sequence of three ribonucleotides in the mRNA chain that codes for a specific amino acid; also a three-nucleotide sequence that is a stop codon and stops translation.

Genetic code: The sequence of nucleotides, coded in triplets (codons) in mRNA that determines the sequence of amino acids in protein synthesis.

Illustrated relationships are:

DNA informational strand: 5’ ATG  CCA   GTA  GGC  CAC   TTG   TCA  3’

DNA Template strand:         3’ TAC  GGT   CAT  CCG  GTG   AAC   AGT  5’

mRNA:                                  5’ AUG  CCA  GUA  GGC  CAC  UUG   UCA  3’

protein:                                       Met    Pro     Val    Gly     His    Leu      Ser

Notice: 5’ end of the mRNA strand codes for the N-terminal amino acid, whereas the 3’ end of the mRNA strand codes for the C-terminal amino acid. Proteins are always written N-terminal to C-terminal, reading left to right.