Concept explainers
Interpretation:
Difference between DNA ligase and DNA polymerase has to be accounted.
Concept Introduction:
Composition of
Base pairing in DNA: The two strands of the DNA double helix run in the opposite directions: one in 5’ to 3’ direction and other from 3’ to 5’ direction (complementary strand). The hydrogen bonding between two strands enhances the stability of the DNA; where the alignment of hydrophobic nitrogenous bases in the interior and hydrophilic phosphate and sugar groups on the exterior, is present that enhance the stability too. Adenine and thymine gives a pair forming two hydrogen bonds and cytosine and guanine gives rise to another pair forming three hydrogen bonds.
Replication of DNA: The process by which copies of DNA are made when a cell divides.
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Fundamentals of General, Organic, and Biological Chemistry (8th Edition)
- What are the chemical bonds of the DNA molecule that are broken for the replication process to occur?arrow_forwardIn terms of new DNA strands that are generated, what are the differences between replication and conventional polymerase chain reactions?arrow_forwardWhat is meant by non-classical DNA-dependent DNA polymerases? What roles do they play in our cells?arrow_forward
- What is the meaning of DNA clone?arrow_forwardIn terms of the new DNA strands that are generated, what are the differences between replication and conventional polymerase chain reaction?arrow_forwardWhat is the end-replication problem? Why, in the absence of telomerase, do the ends of linear chromosomes get progressively shorter each time the DNA is replicated?arrow_forward
- How is DNA synthesis in the Polymerase Chain reaction similar to, or different from, DNA synthesis during genome replication in cells?arrow_forwardIn DNA replication, the role of topoisomerase is to Question 11 options: a) "unzip" the double stranded DNA in front of DNA polymerase. b) maintain the single stranded DNA. c) supercoil the DNA after the replication fork has passed. d) relieve supercoil tension in the DNA in front of the replication fork.arrow_forwardWhich of the followings statements are true about DNA polymerase? 1.) It can only go in one direction, meaning the lagging strand can't be synthesized continuously. 2.) It cannot start a DNA strand from scratch, so another enzyme is needed to create "primers" as a starting point. 3.) It cannot copy epigenetic marks (such as methyl groups) on its own; these must be "copied" onto the daughter DNA strand by other enzymes after DNA replication. 4.) All of the abovearrow_forward
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