A reasonable mechanism for HMG-CoA synthase reaction should be written. Concept Introduction: Acetyl CoA produced by ß oxidation of fatty acids undergoes further oxidation in the TCA cycle. Some of this acetyl CoA is converted into three metabolites; acetone, acetoacetate and ß hydroxybutyrate. Process of formation of these metabolites is known as ketogenesis. Although ß hydroxybutyrate does not have a ketone functional group, those three groups are known as ketone bodies.

Question

Another biochemical study from another patient reveals a 100X increase in the KM value for the enzyme succinyl-CoA synthetase for this individual (only isozyme expressed). What metabolic and physiological consequences would you predict resulting from this enzymatic change?

Answer 1

Question

Definition Definition Organic compounds that have a carbonyl group, C = O, as their functional group. The carbonyl group in ketones is placed somewhere in the middle of the molecular structure, which means, the C=O is attached to two alkyl groups or benzene rings. Just like all other homologous series, the naming of ketones is done using a common suffix “-one”. The general molecular formula is C n H 2n O. Functional group of a ketone

Chapter 23, Problem 13P

Interpretation Introduction

Interpretation:

A reasonable mechanism for HMG-CoA synthase reaction should be written.

Concept Introduction:

Acetyl CoA produced by ß oxidation of fatty acids undergoes further oxidation in the TCA cycle. Some of this acetyl CoA is converted into three metabolites; acetone, acetoacetate and ß hydroxybutyrate. Process of formation of these metabolites is known as ketogenesis. Although ß hydroxybutyrate does not have a ketone functional group, those three groups are known as ketone bodies.

Expert Solution & Answer

Trending nowThis is a popular solution!

See solution

Check out sample textbook solution

Students have asked these similar questions

Another biochemical study from another patient reveals a 100X increase in the KM value for the enzyme succinyl-CoA synthetase for this individual (only isozyme expressed). What metabolic and physiological consequences would you predict resulting from this enzymatic change?

Would the development of a “super statin” that inhibited all HMG CoA reductase activity be a useful drug? Explain.

Calculate the number of ATPS generated from the metabolic oxi- dation of the four carbons of acetoacetyl-CoA to CO,. Now consider the homolog derived from oxidation of an odd-numbered carbon chain, namely propionoacetyl-CoA. Calculate the net ATP yield from oxidation of the five carbons of this compound to CO,.

Answer 2

Question

Definition Definition Organic compounds that have a carbonyl group, C = O, as their functional group. The carbonyl group in ketones is placed somewhere in the middle of the molecular structure, which means, the C=O is attached to two alkyl groups or benzene rings. Just like all other homologous series, the naming of ketones is done using a common suffix “-one”. The general molecular formula is C n H 2n O. Functional group of a ketone

Chapter 23, Problem 13P

Interpretation Introduction

Interpretation:

A reasonable mechanism for HMG-CoA synthase reaction should be written.

Concept Introduction:

Acetyl CoA produced by ß oxidation of fatty acids undergoes further oxidation in the TCA cycle. Some of this acetyl CoA is converted into three metabolites; acetone, acetoacetate and ß hydroxybutyrate. Process of formation of these metabolites is known as ketogenesis. Although ß hydroxybutyrate does not have a ketone functional group, those three groups are known as ketone bodies.

Expert Solution & Answer

Trending nowThis is a popular solution!

See solution

Check out sample textbook solution

Answer 3

Question

Definition Definition Organic compounds that have a carbonyl group, C = O, as their functional group. The carbonyl group in ketones is placed somewhere in the middle of the molecular structure, which means, the C=O is attached to two alkyl groups or benzene rings. Just like all other homologous series, the naming of ketones is done using a common suffix “-one”. The general molecular formula is C n H 2n O. Functional group of a ketone

Chapter 23, Problem 13P

Interpretation Introduction

Interpretation:

A reasonable mechanism for HMG-CoA synthase reaction should be written.

Concept Introduction:

Acetyl CoA produced by ß oxidation of fatty acids undergoes further oxidation in the TCA cycle. Some of this acetyl CoA is converted into three metabolites; acetone, acetoacetate and ß hydroxybutyrate. Process of formation of these metabolites is known as ketogenesis. Although ß hydroxybutyrate does not have a ketone functional group, those three groups are known as ketone bodies.

Expert Solution & Answer

Trending nowThis is a popular solution!

See solution

Check out sample textbook solution

Answer 4

Question

Definition Definition Organic compounds that have a carbonyl group, C = O, as their functional group. The carbonyl group in ketones is placed somewhere in the middle of the molecular structure, which means, the C=O is attached to two alkyl groups or benzene rings. Just like all other homologous series, the naming of ketones is done using a common suffix “-one”. The general molecular formula is C n H 2n O. Functional group of a ketone

Chapter 23, Problem 13P

Interpretation Introduction