The consequences of a deficiency in vitamin B 1 2 for fatty acid oxidation and metabolic intermediate might accumulate should be explained. Concept Introduction: The final product of ß oxidation of fatty acids with odd number of carbon is 3-C propionyl CoA instead of acetyl CoA. Then propionyl CoA is converted into succinyl CoA via several steps. The carboxylation of a propionyl CoA to produce D-methylmalonyl CoA is the first step. The catalyst for the reaction is a biotin dependent enzyme propionyl CoA carboxylase. In the next step, D-methylmalonyl CoA so formed is isomerized into L-isomer by methylmalonyl CoA epimerase. This product is then subjected to methylmalonyl CoA mutase reaction which catalyzes the conversion of L-methylmalonyl CoA into succinyl CoA. This enzyme is vitamin B 1 2 dependent.

Question

Biochemistry What is the process of "transamination" in either the muscles or the liver, that involves keto acid or glutamic acid? Please explain how the steps work. Thank you!

Answer 1

Question

Chapter 23, Problem 7P

Interpretation Introduction

Interpretation:

The consequences of a deficiency in vitamin B₁₂for fatty acid oxidation and metabolic intermediate might accumulate should be explained.

Concept Introduction:

The final product of ß oxidation of fatty acids with odd number of carbon is 3-C propionyl CoA instead of acetyl CoA. Then propionyl CoA is converted into succinyl CoA via several steps.

The carboxylation of a propionyl CoA to produce D-methylmalonyl CoA is the first step. The catalyst for the reaction is a biotin dependent enzyme propionyl CoA carboxylase. In the next step, D-methylmalonyl CoA so formed is isomerized into L-isomer by methylmalonyl CoA epimerase.

This product is then subjected to methylmalonyl CoA mutase reaction which catalyzes the conversion of L-methylmalonyl CoA into succinyl CoA. This enzyme is vitamin B₁₂ dependent.

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