Biochemistry
Biochemistry
6th Edition
ISBN: 9781305577206
Author: Reginald H. Garrett, Charles M. Grisham
Publisher: Cengage Learning
Question
Book Icon
Chapter 23, Problem 10P
Interpretation Introduction

Interpretation:

The consequences of a carnitine deficiency for fatty acid oxidation should be discussed.

Concept Introduction:

Most of the enzymes of ß oxidation pathway are in the mitochondrial matrix. Short chain fatty acids are transported to the matrix as free acids and convert to acyl CoA derivatives. Long chain fatty acids cannot be transported to the matrix directly. Therefore, they must be converted to acylcarnitine derivatives. Carnitine acyltransferase I is associated with the outer mitochondrial membrane. It catalyzes the formation of O-acylcarnitine. This is transported across the inner mitochondrial membrane by translocase. Then acylcarnitine is transferred to carnitine acyltransferase II on matrix side. This enzyme transfers fatty acyl group back to CoA leaving free carnitine which can return across the membrane via translocase.

Blurred answer
Students have asked these similar questions
16. Which one of the compounds below is the final product of the reaction sequence shown here? OH A B NaOH Zn/Hg aldol condensation heat aq. HCI acetone C 0 D E
2. Which one of the following alkenes undergoes the least exothermic hydrogenation upon treatment with H₂/Pd? A B C D E
6. What is the IUPAC name of the following compound? A) (Z)-3,5,6-trimethyl-3,5-heptadiene B) (E)-2,3,5-trimethyl-1,4-heptadiene C) (E)-5-ethyl-2,3-dimethyl-1,5-hexadiene D) (Z)-5-ethyl-2,3-dimethyl-1,5-hexadiene E) (Z)-2,3,5-trimethyl-1,4-heptadiene
Knowledge Booster
Background pattern image
Similar questions
SEE MORE QUESTIONS
Recommended textbooks for you
Text book image
Biochemistry
Biochemistry
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Cengage Learning
Text book image
Human Heredity: Principles and Issues (MindTap Co...
Biology
ISBN:9781305251052
Author:Michael Cummings
Publisher:Cengage Learning
Text book image
Human Physiology: From Cells to Systems (MindTap ...
Biology
ISBN:9781285866932
Author:Lauralee Sherwood
Publisher:Cengage Learning
Text book image
Biology 2e
Biology
ISBN:9781947172517
Author:Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:OpenStax
Text book image
BIOLOGY:CONCEPTS+APPL.(LOOSELEAF)
Biology
ISBN:9781305967359
Author:STARR
Publisher:CENGAGE L
Text book image
Nutritional Sciences: From Fundamentals to Food, ...
Health & Nutrition
ISBN:9781337486415
Author:McGuire
Publisher:Cengage