Why nature uses FAD/FADH 2 as a cofactor in the acyl-CoA dehydrogenase reaction rather than NAD + /NADH should be discussed. Concept Introduction: The enzymes involving in ß oxidation can be subdivided as membrane bound and soluble enzymes in matrix. As fatty acid chain getting short in successive cycles of ß oxidation, fatty acid chain moves from membrane bound complex to matrix. The first step of ß oxidation is oxidation of the bond between a and ß carbon of fatty acid. This reaction is catalyzed by one of four acyl CoA dehydrogenases. They are very long chain acyl CoA dehydrogenase and dehydrogenases specific for long chain, medium chain and short chain. Acyl CoA dehydrogenases non-covalently binds FAD which is reduced to FADH 2 during ß oxidation.

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Chapter 23, Problem 19P

Interpretation Introduction

Interpretation:

Why nature uses FAD/FADH₂ as a cofactor in the acyl-CoA dehydrogenase reaction rather than NAD⁺/NADH should be discussed.

Concept Introduction:

The enzymes involving in ß oxidation can be subdivided as membrane bound and soluble enzymes in matrix. As fatty acid chain getting short in successive cycles of ß oxidation, fatty acid chain moves from membrane bound complex to matrix. The first step of ß oxidation is oxidation of the bond between a and ß carbon of fatty acid. This reaction is catalyzed by one of four acyl CoA dehydrogenases. They are very long chain acyl CoA dehydrogenase and dehydrogenases specific for long chain, medium chain and short chain. Acyl CoA dehydrogenases non-covalently binds FAD which is reduced to FADH₂ during ß oxidation.

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