Biochemistry
Biochemistry
6th Edition
ISBN: 9781305577206
Author: Reginald H. Garrett, Charles M. Grisham
Publisher: Cengage Learning
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Chapter 23, Problem 14P
Interpretation Introduction

Interpretation:

A reasonable mechanism for the methylmalonyl CoA mutase reaction should be written.

Concept Introduction:

Humans and animals can metabolize fatty acids with odd number of carbons via the ß oxidation pathway. The final product of this pathway is 3-C propionyl CoA instead of acetyl CoA. Then three enzymes catalyze the conversion of propionyl CoA into succinyl CoA.

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H2C CH2 HC-COOO CH2 ܘHO-C-13c-O isocitrate C-S-COA H213c CH2 C-OO 13C-S-COA CH2 C-00 the label will not be present in succinyl CoA C-S-COA succinyl-CoA
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