Biochemistry
6th Edition
ISBN: 9781305577206
Author: Reginald H. Garrett, Charles M. Grisham
Publisher: Cengage Learning
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Chapter 23, Problem 14P
Interpretation Introduction
Interpretation:
A reasonable mechanism for the methylmalonyl CoA mutase reaction should be written.
Concept Introduction:
Humans and animals can
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H.
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1-isopropylmalate
2-isopropylmalate
Biosynthesis of leucine involves conversion of 1-isopropyimalate to 2-isopropylmalate (see above). This proceeds in four steps under basic
enzymic catalysis via an isolable compound produced in step 2. Write a detailed mechanism for this conversion. Then, draw the intermediate
compound) produced in step 2.
• You do not have to consider stereochemistry.
• Draw uninvolved carboxyl groups in the anionic state, and enolates as carbanions.
When needed, abbreviate CoenzymeA-S- as CH3S- In your drawing.
aale
. Pyruvate can be processed under anaerobic conditions to ethanol (in yeast) or to lactate (in
mammals), as shown.
Explain the primary purpose of these reactions.
Describe the major biochemical features of each reaction
Compare and contrast Pyruvate Dehydrogenase with a-ketoglutarate dehydrogenaseOutline the mechanisms of both enzymes. Discuss the functions of the coenzymes. List the similarities and the differences between the 2 enzymes. Both are very large membrane bound complexes. What are the advantages of this strategy?How detailed is the enzyme structure known below(It's Pyruvate Dehydrogenase )? What insight(s) does this structural detail give you about the enzyme mechanism.
Chapter 23 Solutions
Biochemistry
Ch. 23 - Prob. 1PCh. 23 - Determining the Amount of ATP Produced from Fatty...Ch. 23 - Prob. 3PCh. 23 - Examining the Labeling of Glucose from 14C.labeled...Ch. 23 - Prob. 5PCh. 23 - Prob. 6PCh. 23 - Prob. 7PCh. 23 - Prob. 8PCh. 23 - Prob. 9PCh. 23 - Prob. 10P
Ch. 23 - Prob. 11PCh. 23 - Understanding Human Energy Consumption During...Ch. 23 - Prob. 13PCh. 23 - Prob. 14PCh. 23 - Prob. 15PCh. 23 - Extending the Mechanism of Methylmalonyl-CoA...Ch. 23 - Prob. 17PCh. 23 - Prob. 18PCh. 23 - Prob. 19PCh. 23 - Understanding a Ubiquitous Series of Metabolic...Ch. 23 - Using the ActiveModel for enoyl-CoA dehydratase,...
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- Using the ActiveModel for enoyl-CoA dehydratase, give an example of a case in which conserved residues in slightly different positions can change the catalytic rate of reaction.arrow_forwardGive detailed Solution with explanation needed (no need Handwritten answerarrow_forwardDetermine the yield in water for the complete oxidation of 1 molecule of a triglyceride containing 3, C16 fatty acids. Please do not show the (7-C)-6 formula. Can you please show me where each water molecule comes from that is considered for this calculation (TCA, ETC, B-oxidation and ATP synthase)? Thank you!arrow_forward
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