ORGANIC CHEMISTRY-PRINT MULTI TERM
ORGANIC CHEMISTRY-PRINT MULTI TERM
4th Edition
ISBN: 9781119832614
Author: Klein
Publisher: WILEY
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Chapter 22, Problem 89IP
Interpretation Introduction

Interpretation: An efficient synthesis for the given compound has to be proposed using benzene as carbon source and ammonia as nitrogen source

Concept Introduction:

Reductive amination: Sodium cyanoborohydride is a strong reducing agent than sodium borohydride.  It reduces the carbonyl group into amine group in a rapid way.  So, it is called as reductive amination reactions.  Aldehyde or ketone group is reacted with ammonia in the presence of sodium cyanoborohydride as a reducing agent and a proton source in the reaction medium to produce primary amines.

ORGANIC CHEMISTRY-PRINT MULTI TERM, Chapter 22, Problem 89IP , additional homework tip  1

Birch reduction: Birch reduction is an organic reaction where aromatic rings undergo a 1,4-reduction to provide unconjugated cyclohexadienes. The reduction is conducted by sodium or lithium metal in liquid ammonia and in the presence of an alcohol.

ORGANIC CHEMISTRY-PRINT MULTI TERM, Chapter 22, Problem 89IP , additional homework tip  2

To find: Propose an efficient synthesis for the given compound using benzene as carbon source and ammonia as nitrogen source

Apply a retrosynthetic analysis

ORGANIC CHEMISTRY-PRINT MULTI TERM, Chapter 22, Problem 89IP , additional homework tip  3

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Chapter 22 Solutions

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