Introduction To Genetic Analysis
12th Edition
ISBN: 9781319114787
Author: Anthony J.F. Griffiths, John Doebley, Catherine Peichel, David A. Wassarman
Publisher: W. H. Freeman
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Chapter 2, Problem 3GS
Summary Introduction
To determine: The role of heterozygosity of recessice Mendelian alleles in family planning.
Introduction. Genetic testing is one of the most useful tools in diagnostics to identify genetic abnormalities. It helps to detect the presence of any heritable malformation carried through the genetic makeup of the parents to the offspring.
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what is the probability that a couple (both heterozygous for the same recessive mutation) will have two children with the disease if the couple plans to have four children in total?
A couple is going to have a baby. They are concerned about sickle cell anemia, which results from having the homozygous recessive combination of the sickle cell gene ("s"), which produces abnormal hemoglobin. Having at least one normal version of the gene ("S") results in normal hemoglobin. The woman is heterozygous, and so is the man.
What alleles does mom have?
What alleles does dad have?
For a recessive condition, two normal heterozygous individuals have children.
What is the likelihood of their children being affected by this condition?
What is the likelihood of their children being carriers without the condition?
What is the likelihood of their asymptomatic children being carriers?
Suppose that an individual with the condition has children with a heterozygous individual, what is the likelihood of their children being carriers?
Chapter 2 Solutions
Introduction To Genetic Analysis
Ch. 2 - Prob. 1PCh. 2 - Prob. 2PCh. 2 - Prob. 3PCh. 2 - Prob. 4PCh. 2 - Prob. 5PCh. 2 - Prob. 6PCh. 2 - Prob. 7PCh. 2 - Prob. 8PCh. 2 - Prob. 9PCh. 2 - Prob. 10P
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- Cystic fibrosis is a disease that is passed down through the generations. The recessive alleles for cystic fibrosis are heterozygous carriers in both parents. What is the probability that one of their children may develop cystic fibrosis?arrow_forwardHemophilia is a sex-linked recessive trait. A male hemophiliac and phenotypically normal female have a son with hemophilia. They would like to have one more child. What is the probability of having a child without hemophilia? Explain using a Punnett square. Is it possible for a girl to be born with hemophilia? Explain.arrow_forwardPhenylketonuria (PKU) is a recessive disorder that neither Ginny or Harry have. Unfortunately, their son Albus is affected with this condition. What are the chances that Ginny and Harry's next child will be a carrier for PKU? O 50% O 25% O 100% O 75% O 0%arrow_forward
- Marly is doing a paternity test to determine who could be her father. She is going just off of word of mouth for now so there is no way for her to figure out the genotypes of ther potential fathers. She knows for certain that she is type A with the genotype (A^I A^i). Her potential fathers are Gayle who is a Type O, Jake who is type A,and Mark who is Type AB. Who could be the potential father?arrow_forwardAlbinism and sickle cell anemia are both autosomal recessive disorders that are expressed only in the homozygous state. Two parents who are carriers for both albinism and sickle cell anemia plan to have a child. What is the probability that the child will have exactly one of the conditions? 3/8 7/16 O 1/16 O 1/4 9/16arrow_forwardA woman knows that her mother is a carrier of Kartagener’s syndrome (an autosomal recessive disorder). The woman does not know if either she or her husband are carriers. The couple wants to have a child, but is worried about whether or not they could have a child with Kartagener’s syndrome. Should the couple seek the advice of a genetic counselor? In other words, is there a chance they could have an affected child? If there is a chance, please make sure your answer includes the specific parental genotypes necessary to make this possible.arrow_forward
- hemophilia is a sex linked recessive disease. Dick does not have hemophilia. His wife Debi is a heterozygote. They are having fraternal twins, one of each sex, who they have named Dick Jr. and Debi Jr. What are the chances of Dick Jr. having hemophilia? Debi Jr.?arrow_forwardA recently married couple are both heterozygous for cystic fibrosis, a recessive genetic disorder. They would like to start a family and would like to have two children. What is the probability that both their first and second child would have cystic fibrosis?arrow_forwardMary and Ron don't have albinism. However, is it possible for them to have a child with albinism? Explain. Stephanie has normal color vision. Her husband Chris also has normal color vision. They have a son that is color blind and a daughter that has normal color vision. What is the genotype of the mother, father, son and the daughter? Andy and Anne do not have polydactyl. Is it possible for them to have a child with polydactyl? Explain. When examining a pedigree chart, I notice that only males are affected. What does this tell me about the inheritance pattern? A man with blood type A marries a woman with blood type B. Their child has blood type O. What are the genotypes of the parents?arrow_forward
- Hemophilia is an X-linked recessive disorder and blood type is autosomal. If two healthy parents, one of which is blood type A and the other blood type B, produce a son who has hemophilia and is type O, what is the probability that their next child will be a son with hemophilia and blood type B? 1/2 3/16 1/4 1/8 1/16arrow_forwardIn a cross between an individual with Huntington disease and an unaffected individual, what are the chances their progeny will have the disease, considering that it is a dominant trait?arrow_forwardAlbinism is an autosomal recessive condition characterized by absence of melanin pigment from the skin, eye and hair. Two carriers of albinism marry and plan to have FIVE children. Assume a 1:1 sex ratio. What is the probability that at least 3 children will be normal?arrow_forward
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