Introduction To Genetic Analysis
12th Edition
ISBN: 9781319114787
Author: Anthony J.F. Griffiths, John Doebley, Catherine Peichel, David A. Wassarman
Publisher: W. H. Freeman
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Chapter 2, Problem 56.1P
Summary Introduction
To determine: The representation of the hereditary pattern of galactosemia in a pedigree chart.
Introduction. Pedigree analysis is the study of the hereditary patterns of the various generations of the family. The pedigree analysis helps to track the origin and the way a disease is being inherited in a family. Various symbols are used to depict various members along with the affected and unaffected individuals in the family.
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Salim and Sara are contemplating having children, but Salim’s brother has galactosemia and Sara’s great-grandmother also had galactosemia. Sara has a sister who has three children, none of whom is affected.
What is the probability that Salim and Sara’s first child will have galactosemia? Explain your calculations.
Ann's family has a history of cystic fibrosis, a recessive genetic disease. In the pedigree, family members who are afflicted with the disease are shown in red. Members who are unafflicted may or may not be carriers. Which of the given family members can be identified definitively as unafflicted carriers of cystic fibrosis?
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Chapter 2 Solutions
Introduction To Genetic Analysis
Ch. 2 - Prob. 1PCh. 2 - Prob. 2PCh. 2 - Prob. 3PCh. 2 - Prob. 4PCh. 2 - Prob. 5PCh. 2 - Prob. 6PCh. 2 - Prob. 7PCh. 2 - Prob. 8PCh. 2 - Prob. 9PCh. 2 - Prob. 10P
Ch. 2 - Prob. 11PCh. 2 - Prob. 12PCh. 2 - Prob. 13PCh. 2 - Prob. 14PCh. 2 - Prob. 15PCh. 2 - Prob. 17PCh. 2 - Prob. 18PCh. 2 - Prob. 19PCh. 2 - Prob. 20PCh. 2 - Prob. 21PCh. 2 - Prob. 22PCh. 2 - Prob. 23PCh. 2 - Prob. 24PCh. 2 - Prob. 25PCh. 2 - Prob. 26PCh. 2 - Prob. 27PCh. 2 - Prob. 28PCh. 2 - Prob. 29PCh. 2 - Prob. 30PCh. 2 - Prob. 31PCh. 2 - Prob. 32PCh. 2 - Prob. 33PCh. 2 - Prob. 34PCh. 2 - Prob. 35PCh. 2 - Prob. 36PCh. 2 - Prob. 37PCh. 2 - Prob. 38PCh. 2 - Prob. 39PCh. 2 - Prob. 40PCh. 2 - Prob. 41PCh. 2 - Prob. 42PCh. 2 - Prob. 43PCh. 2 - Prob. 44PCh. 2 - Prob. 45PCh. 2 - Prob. 46PCh. 2 - Prob. 47PCh. 2 - Prob. 48PCh. 2 - Prob. 49PCh. 2 - Prob. 50PCh. 2 - Prob. 51PCh. 2 - Prob. 52PCh. 2 - Prob. 53PCh. 2 - Prob. 54PCh. 2 - Prob. 55PCh. 2 - Prob. 56PCh. 2 - Prob. 56.1PCh. 2 - Prob. 56.2PCh. 2 - Prob. 56.3PCh. 2 - Prob. 56.4PCh. 2 - Prob. 56.5PCh. 2 - Prob. 56.6PCh. 2 - Prob. 56.7PCh. 2 - Prob. 56.8PCh. 2 - Prob. 56.9PCh. 2 - Prob. 56.10PCh. 2 - Prob. 56.11PCh. 2 - Prob. 56.12PCh. 2 - Prob. 56.13PCh. 2 - Prob. 56.14PCh. 2 - Prob. 56.15PCh. 2 - Prob. 57PCh. 2 - Prob. 58PCh. 2 - Prob. 59PCh. 2 - Prob. 60PCh. 2 - Prob. 61PCh. 2 - Prob. 62PCh. 2 - Prob. 63PCh. 2 - Prob. 64PCh. 2 - Prob. 65PCh. 2 - Prob. 67PCh. 2 - Prob. 68PCh. 2 - Prob. 69PCh. 2 - Prob. 70PCh. 2 - Prob. 71PCh. 2 - Prob. 72PCh. 2 - Prob. 73PCh. 2 - Prob. 74PCh. 2 - Prob. 75PCh. 2 - Prob. 76PCh. 2 - Prob. 77PCh. 2 - Prob. 78PCh. 2 - Prob. 79PCh. 2 - Prob. 80PCh. 2 - Prob. 81PCh. 2 - Prob. 82PCh. 2 - Prob. 83PCh. 2 - Prob. 84PCh. 2 - Prob. 85PCh. 2 - Prob. 86PCh. 2 - Prob. 87PCh. 2 - Prob. 88PCh. 2 - Prob. 89PCh. 2 - Prob. 90PCh. 2 - Prob. 91PCh. 2 - Prob. 1GSCh. 2 - Prob. 2GSCh. 2 - Prob. 3GS
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- Ann's family has a history of cystic fibrosis, a recessive genetic disease. In the pedigree, family members who are afflicted with the disease are shown in red. Members who are unafflicted may or may not be carriers. Which of the given family members can be identified definitively as unafflicted carriers of cystic fibrosis? Unafflicted carriers Ann Answer Bank father aunt's husband grandmother sister unclearrow_forwardMartin and Sue are contemplating having children, but Martin’s brother has an autosomal recessive disease and Sue’s great-grandmother also had the same disease. Sue has a sister who has three normal, healthy children. What is the probability that Martin and Sue’s first child will have the autosomal recessive disease? HINT draws out pedigree charts and punnett squares for Martin and Sue.arrow_forwardMuffy, a color blind female with blood type A (heterozygous to type O) is married to Biff, who is also color blind and is homozygous for type B blood. Muffy has been having an affair with their gardener, Raoul, who is heterozygous for type B blood and has normal vision. Recall that color blindness is a sex linked recessive condition. Please help Biff's attorney determine the father of each of the children for the divorce proceedings. Show ALL work using punnett squares. a) female, type A blood, normal vision b) male, type O blood, color blind c) female, type AB blood, color blindarrow_forward
- Salim and Sara are contemplating having children, but Salim’s brother has galactosemia and Sara has a sister who has three children, none of whom is affected. Sara dad has no history in his family of any sign of the diease and it is assumed to be homozygous normal. What is the probability that salim and saras first child will have galactosemia?arrow_forwardInigo Montoya is healthy but his mother had the recessive condition, cystic fibrosis, which is autosomal. Buttercup marries Inigo and through genetic testing finds out that she is a carrier of the allele causing cystic fibrosis. What is the probability that their first three children will have cystic fibrosis? Show your calculations.arrow_forwardSalim and Sara are contemplating having children, but Salim’s brother has galactosemia and Sara has a sister who has three children, one of whom is affected. Sara dad has no history in his family of any sign of the diease and it is assumed to be homozygous normal. What is the probability that salim and saras first child will have galactosemia?arrow_forward
- John and Sue are expecting a child, but are concerned about a rare autosomal recessive disease that is present in both of their families. In the pedigree, John is represented as individual III-11 and Sue is represented as individual III-12; both are unaffected. John's sister, III-10, and Sue's brother, III-13, both do not show evidence of the disease, but John's paternal grandmother and Sue's maternal grandfather both had the disease. Assign the appropriate symbol to each individual in the pedigree. I 3 4. Answer Bank II III 11 12 13 10 2.arrow_forwardCystic fibrosis is a genetic disease that causes an abnormal production of mucus which in turn can cause damage and infection to the lungs and other organs. In the following pedigree, black indicates all those persons afflicted with cystic fibrosis (square symbols are males, circles are females). There's a healthy couple and they have two children. One is a 23-year-old daughter with cystic fibrosis who is married to a 24-year-old male who is healthy. The other child is a 15-year-old son who is healthy After studying the pedigree, write a logical hypothesis suggesting the cause of cystic fibrosis in terms of dominant or recessive alleles. On the basis of your hypothesis, write an appropriate genotype for both of the parents. Using a Punnett square, what is the probability of the parents having a child with cystic fibrosis? If the daughter's husband is a carrier of cystic fibrosis, what is the probability that they have a child with cystic fibrosis? Show your Punnett square.arrow_forwardA cross between two red flower plants produces 2/3 progeny that are red and1/3 progeny that are yellow. What is the genotype of the red flower? Explain these unexpected ratios.arrow_forward
- Explain why it is possible for the proband in the following pedigree to have children of blood types A, B, and AB. Considering epistatic genes, what are the possible genotypes of II-2?arrow_forwardJohn and Sue are expecting a child, but are concerned about a rare autosomal recessive disease that is present in both of their families. In the pedigree, John is represented as individual III‑11 and Sue is represented as individual III‑12; both are unaffected. John's sister, III‑10, and Sue's brother, III‑13, both do not show evidence of the disease, but John's paternal grandmother and Sue's maternal grandfather both had the disease. What is the probability that neither John nor Sue is a carrier?arrow_forwardThis is a typical pedigree for a family that carries neurofibromatosis. Is individual I-2 most likely homozygous or heterozygous? Why? Explain.arrow_forward
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