Concept explainers
a.
To determine: The probability that the child will have cystic fibrosis.
Introduction: Cystic fibrosis is a genetic disease often affecting the lungs and also the pancreas, liver, kidneys, and intestine. The long-term effects involve difficulty in breathing and coughing up mucus as a consequence of repeated lung infections.
b.
To determine: The chance that the children will have the precise Mendelian ratio of 3:1 for normal cystic fibrosis.
Introduction: The Mendelian ratio exists of several
c.
To determine: The probability that their next three children will be normal, if their first child has cystic fibrosis.
Introduction: Cystic fibrosis is a continuous genetic disorder that induces persistent infections in the lung and restricts the strength to breathe over time. In people with CF, mutations within the transmembrane of cystic fibrosis conductance regulator gene cause the CFTR protein to become dysfunctional.

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Chapter 2 Solutions
Introduction To Genetic Analysis
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- The following figure is from Caterina et al. The capsaicin receptor: a heat activated ion channel in the pain pathway. Nature, 1997. Black boxes indicate capsaicin, white circles indicate resinferatoxin. a) Which has a higher potency? b) Which is has a higher efficacy? c) What is the approximate Kd of capsaicin in uM? (you can round to the nearest power of 10)arrow_forwardWhat is the rate-limiting-step for serotonin synthesis?arrow_forwardWhat enzyme is necessary for synthesis of all of the monoamines?arrow_forward
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