
Interpretation:
To determine the retrosynthetic analysis and synthesis of the following compounds.
Concept introduction:
Grignard reagents and organolithium compounds are strong bases. They will react with compounds containing hydrogen, attached to electronegative atoms like oxygen, nitrogen, and sulfur. They can be denoted as follows:
Grignard reagent reactions with carbonyl groups are treated as acid–base reactions. Grignard reagents are strong bases. When a reaction between a strong base and strong acid occurs, weak acid and weak base are formed. The side of the reaction that has the weak acid and base is favored.
Lithium aluminum hydride or sodium borohydride are used as reducing agents. Sodium borohydride is better for reducing
Retrosynthetic analysis is backtracking the reactants in a series of reactions. For synthesis of a compound using Grignard reagents, we have to select the correct reagents, ethers, aldehydes, ketones, or esters. There might be multiple ways to synthesize the alcohol and depending on the availability of reagents, we can choose a specific method.

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Chapter 12 Solutions
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