Genetics: From Genes to Genomes, 5th edition
5th Edition
ISBN: 9780073525310
Author: Leland H. Hartwell, Michael L. Goldberg, Janice A. Fischer, Leroy Hood, Charles F. Aquadro
Publisher: McGraw-Hill Education
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Chapter 10, Problem 28P
The pedigree shown in Fig. 10.22 on p.360 was critical to the identification of the Huntington disease gene HD, which is located on chromosome 4.
| a. | The data show that the DNA marker G8 is clearly linked to HD. For the large majority of the people in the pedigree with Huntington disease, which allele of G8 (A, B, C, or D) did they inherit, along with the dominant disease-causing allele of HD, on the copy of chromosome 4 from their affected parent? |
| b. | How many people in the pedigree can you categorize absolutely as the product of parental or recombinant gametes from their affected parent, without making any assumptions at all (including the assumption of linkage)? |
| c. | If you now make the assumption that G8 and HD are linked, how many of the people in this pedigree must be the product of a recombinant gamete from their affected parent? |
| d. | Based solely on the data from this pedigree, what would be the best estimate for the map distance between G8 and HD? |
| e. | Considering your answers to parts (b) through (d), calculate the maximum Lod score. The pedigree contains 46 people resulting from informative matings. (Note that 00 = 1.) What does this Lod score signify? |
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Chapter 10 Solutions
Genetics: From Genes to Genomes, 5th edition
Ch. 10 - Choose the phrase from the right column that best...Ch. 10 - Would you characterize the pattern of inheritance...Ch. 10 - Would you be more likely to find single nucleotide...Ch. 10 - A recent estimate of the rate of base...Ch. 10 - If you examine Fig. 10.5 on p. 344 closely, you...Ch. 10 - Approximately 50 million SNPs have thus far been...Ch. 10 - Mutations at simple sequence repeat SSR loci occur...Ch. 10 - Humans and gorillas last shared a common ancestor...Ch. 10 - Using PCR, you want to amplify an approximately 1...Ch. 10 - Prob. 10P
Ch. 10 - Prob. 11PCh. 10 - Prob. 12PCh. 10 - shows three different sequences of the same...Ch. 10 - The trinucleotide repeat region of the Huntington...Ch. 10 - Prob. 15PCh. 10 - Prob. 16PCh. 10 - a. It is possible to perform DNA fingerprinting...Ch. 10 - On July 17, 1918, Tsar Nicholas II; his wife the...Ch. 10 - The figure below shows DNA fingerprint analysis of...Ch. 10 - Microarrays were used to determine the genotypes...Ch. 10 - A partial sequence of the wild-type HbA allele is...Ch. 10 - Prob. 22PCh. 10 - Prob. 23PCh. 10 - The microarray shown at the top of this page...Ch. 10 - The figure below shows the pedigree of a family in...Ch. 10 - Prob. 26PCh. 10 - Now consider a mating between consanguineous...Ch. 10 - The pedigree shown in Fig. 10.22 on p.360 was...Ch. 10 - You have identified a SNP marker that in one large...Ch. 10 - The pedigrees indicated here were obtained with...Ch. 10 - Approximately 3 of the population carries a mutant...Ch. 10 - The drug ivacaftor has recently been developed to...Ch. 10 - In the high-throughput DNA sequencing protocol...Ch. 10 - A researcher sequences the whole exome of a...Ch. 10 - As explained in the text, the cause of many...Ch. 10 - Figure 10.26 on p. 366 portrayed the analysis of...Ch. 10 - Prob. 37PCh. 10 - Table 10.2 p. 367 and Fig. 10.27 p. 367 together...Ch. 10 - The human RefSeq of the entire first exon of a...
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