Glitazones reduce insulin resistance by binding to a transcription factor in adipocytes, thereby reducing thesecretion of fatty acids. Glitazones are taken orally (in pill form). Using pharmacokinetic modeling, deriveequations to describe how the concentration of glitazones varies in the plasma as a function of time. Yourequations should be of the form: dCglitazone /dt = something, or dMglitazone /dt = something. Your model shouldinclude three compartments: the gut, the plasma, and the fatty tissues. Make sure to include a diagram thatillustrates your thinking, state all assumptions, and define your variables. Do not solve the equations.
Glitazones reduce insulin resistance by binding to a transcription factor in adipocytes, thereby reducing thesecretion of fatty acids. Glitazones are taken orally (in pill form). Using pharmacokinetic modeling, deriveequations to describe how the concentration of glitazones varies in the plasma as a function of time. Yourequations should be of the form: dCglitazone /dt = something, or dMglitazone /dt = something. Your model shouldinclude three compartments: the gut, the plasma, and the fatty tissues. Make sure to include a diagram thatillustrates your thinking, state all assumptions, and define your variables. Do not solve the equations.
Chapter9: Parenteral Medication Labels And Dosage Calculation
Section: Chapter Questions
Problem 5.3P
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Glitazones reduce insulin resistance by binding to a transcription factor in adipocytes, thereby reducing the
secretion of fatty acids. Glitazones are taken orally (in pill form). Using pharmacokinetic modeling, derive
equations to describe how the concentration of glitazones varies in the plasma as a function of time. Your
equations should be of the form: dCglitazone /dt = something, or dMglitazone /dt = something. Your model should
include three compartments: the gut, the plasma, and the fatty tissues. Make sure to include a diagram that
illustrates your thinking, state all assumptions, and define your variables. Do not solve the equations.
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