a. To determine: The amount of CAG repeats in the HD + alleles of the given two patients. Introduction: The neurogenerative diseases caused by genes with unstable trinucleotide repeats are divided into two categories. One is polyQ diseases, and the other is non-polyQ diseases where Q represent the amino acid glutamine.

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Answer 1

Question

Chapter 10, Problem 15P

Summary Introduction

a.

To determine:

The amount of CAG repeats in the HD⁺ alleles of the given two patients.

Introduction:

The neurogenerative diseases caused by genes with unstable trinucleotide repeats are divided into two categories. One is polyQ diseases, and the other is non-polyQ diseases where Q represent the amino acid glutamine.

Summary Introduction

b.

To determine:

The justification about the processes which results in mutation in HD alleles along with the type of cells in which these processes take place.

Introduction:

In polyQ disease genes, the repeated triplet is always CAG, whereas, in non-polyQ disease genes, the trinucleotide repeat may be CGG, CTG, GCC, or GAA. These two types of diseases are distinguished based on the effect of the repeated sequence on gene function.

Summary Introduction

c.

To determine:

The reason that patients with Huntington disease have no family history.

Introduction:

The Huntington disease is an inherited disorder which causes the death of brain cells. The disease initiates in the age of 30s or 40s. It can cause impaired movement, loss of thinking ability, and psychiatric symptoms.

Summary Introduction

d.

To determine:

The result if the PCR analysis performed on single skin cells instead of a single sperm.

Introduction:

The polymerase chain reaction is a method of producing multiple copies of specific DNA sequence. It involves three steps, denaturation, annealing, and elongation. The PCR exponentially amplify the desired segment in very less time.

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Explain why you chose this mutation. Begin by transcribing and translating BOTH the normal and abnormal DNA sequences. The genetic code below is for your reference. SECOND BASE OF CODON כ FIRST BASE OF CODON O THIRD BASE OF CODON SCAGUCAGUGAGUCAG UUU UUC UCU UAU UGU Phenylalanine (F) Tyrosine (Y) Cysteine (C) UCC UAC UGC Serine (S) UUA UUG Leucine (L) UCA UCG_ UAA UGA Stop codon -Stop codon UAG UGG -Tryptophan (W) CUU CUC CCU CAU CGU Histidine (H) CCC CAC CGC -Leucine (L) Proline (P) CUA CCA CAA CUG CCG CAG-Glutamine (Q) -Arginine (R) CGA CGG AUU ACU AAU AGU AUC Isoleucine (1) Asparagine (N) ACC AAC Threonine (T) AUA ACA AAA Methionine (M) Lysine (K) AUG ACG Start codon AAG AGC-Serine (S) -Arginine (R) AGA AGG GUU GCU GAU GUC GUA GUG GCC Valine (V) -Alanine (A) GCA GCG GAC GAA GAG Aspartic acid (D) GGU Glutamic acid (E) GGC GGA GGG Glycine (G) In order to provide a complete answer to the question stated above, fill in the mRNA bases and amino acid sequences by using the Genetic Code…

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Answer 2

Question

Chapter 10, Problem 15P

Summary Introduction

a.

To determine:

The amount of CAG repeats in the HD⁺ alleles of the given two patients.

Introduction:

The neurogenerative diseases caused by genes with unstable trinucleotide repeats are divided into two categories. One is polyQ diseases, and the other is non-polyQ diseases where Q represent the amino acid glutamine.

Summary Introduction

b.

To determine:

The justification about the processes which results in mutation in HD alleles along with the type of cells in which these processes take place.

Introduction:

In polyQ disease genes, the repeated triplet is always CAG, whereas, in non-polyQ disease genes, the trinucleotide repeat may be CGG, CTG, GCC, or GAA. These two types of diseases are distinguished based on the effect of the repeated sequence on gene function.

Summary Introduction

c.

To determine:

The reason that patients with Huntington disease have no family history.

Introduction:

The Huntington disease is an inherited disorder which causes the death of brain cells. The disease initiates in the age of 30s or 40s. It can cause impaired movement, loss of thinking ability, and psychiatric symptoms.

Summary Introduction

d.

To determine:

The result if the PCR analysis performed on single skin cells instead of a single sperm.

Introduction:

The polymerase chain reaction is a method of producing multiple copies of specific DNA sequence. It involves three steps, denaturation, annealing, and elongation. The PCR exponentially amplify the desired segment in very less time.

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See solution

Answer 3

Question

Chapter 10, Problem 15P

Summary Introduction

a.

To determine:

The amount of CAG repeats in the HD⁺ alleles of the given two patients.

Introduction:

The neurogenerative diseases caused by genes with unstable trinucleotide repeats are divided into two categories. One is polyQ diseases, and the other is non-polyQ diseases where Q represent the amino acid glutamine.

Summary Introduction

b.

To determine:

The justification about the processes which results in mutation in HD alleles along with the type of cells in which these processes take place.

Introduction:

In polyQ disease genes, the repeated triplet is always CAG, whereas, in non-polyQ disease genes, the trinucleotide repeat may be CGG, CTG, GCC, or GAA. These two types of diseases are distinguished based on the effect of the repeated sequence on gene function.

Summary Introduction

c.

To determine:

The reason that patients with Huntington disease have no family history.

Introduction:

The Huntington disease is an inherited disorder which causes the death of brain cells. The disease initiates in the age of 30s or 40s. It can cause impaired movement, loss of thinking ability, and psychiatric symptoms.

Summary Introduction

d.

To determine:

The result if the PCR analysis performed on single skin cells instead of a single sperm.

Introduction:

The polymerase chain reaction is a method of producing multiple copies of specific DNA sequence. It involves three steps, denaturation, annealing, and elongation. The PCR exponentially amplify the desired segment in very less time.

Expert Solution & Answer

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Check out a sample textbook solution

See solution

Answer 4

Question

Chapter 10, Problem 15P

Summary Introduction

a.

To determine:

The amount of CAG repeats in the HD⁺ alleles of the given two patients.

Introduction:

The neurogenerative diseases caused by genes with unstable trinucleotide repeats are divided into two categories. One is polyQ diseases, and the other is non-polyQ diseases where Q represent the amino acid glutamine.

Summary Introduction

b.

To determine:

The justification about the processes which results in mutation in HD alleles along with the type of cells in which these processes take place.

Introduction:

In polyQ disease genes, the repeated triplet is always CAG, whereas, in non-polyQ disease genes, the trinucleotide repeat may be CGG, CTG, GCC, or GAA. These two types of diseases are distinguished based on the effect of the repeated sequence on gene function.

Summary Introduction

c.

To determine:

The reason that patients with Huntington disease have no family history.

Introduction:

The Huntington disease is an inherited disorder which causes the death of brain cells. The disease initiates in the age of 30s or 40s. It can cause impaired movement, loss of thinking ability, and psychiatric symptoms.

Summary Introduction

d.

To determine:

The result if the PCR analysis performed on single skin cells instead of a single sperm.

Introduction:

The polymerase chain reaction is a method of producing multiple copies of specific DNA sequence. It involves three steps, denaturation, annealing, and elongation. The PCR exponentially amplify the desired segment in very less time.

Expert Solution & Answer

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Check out a sample textbook solution

See solution

Answer 5

Chapter 10, Problem 15P

Summary Introduction

a.

To determine:

The amount of CAG repeats in the HD⁺ alleles of the given two patients.

Introduction:

The neurogenerative diseases caused by genes with unstable trinucleotide repeats are divided into two categories. One is polyQ diseases, and the other is non-polyQ diseases where Q represent the amino acid glutamine.

Summary Introduction

b.

To determine:

The justification about the processes which results in mutation in HD alleles along with the type of cells in which these processes take place.

Introduction:

In polyQ disease genes, the repeated triplet is always CAG, whereas, in non-polyQ disease genes, the trinucleotide repeat may be CGG, CTG, GCC, or GAA. These two types of diseases are distinguished based on the effect of the repeated sequence on gene function.

Summary Introduction

c.

To determine:

The reason that patients with Huntington disease have no family history.

Introduction:

The Huntington disease is an inherited disorder which causes the death of brain cells. The disease initiates in the age of 30s or 40s. It can cause impaired movement, loss of thinking ability, and psychiatric symptoms.

Summary Introduction

d.

To determine:

The result if the PCR analysis performed on single skin cells instead of a single sperm.

Introduction:

The polymerase chain reaction is a method of producing multiple copies of specific DNA sequence. It involves three steps, denaturation, annealing, and elongation. The PCR exponentially amplify the desired segment in very less time.

Answer 6

Chapter 10, Problem 15P

Summary Introduction

a.

To determine:

The amount of CAG repeats in the HD⁺ alleles of the given two patients.

Introduction:

The neurogenerative diseases caused by genes with unstable trinucleotide repeats are divided into two categories. One is polyQ diseases, and the other is non-polyQ diseases where Q represent the amino acid glutamine.

Answer 7

Chapter 10, Problem 15P

Summary Introduction

a.

To determine:

The amount of CAG repeats in the HD⁺ alleles of the given two patients.

Introduction:

The neurogenerative diseases caused by genes with unstable trinucleotide repeats are divided into two categories. One is polyQ diseases, and the other is non-polyQ diseases where Q represent the amino acid glutamine.

Answer 8

Summary Introduction

b.

To determine:

The justification about the processes which results in mutation in HD alleles along with the type of cells in which these processes take place.

Introduction:

In polyQ disease genes, the repeated triplet is always CAG, whereas, in non-polyQ disease genes, the trinucleotide repeat may be CGG, CTG, GCC, or GAA. These two types of diseases are distinguished based on the effect of the repeated sequence on gene function.

Answer 9

Summary Introduction

b.

To determine:

The justification about the processes which results in mutation in HD alleles along with the type of cells in which these processes take place.

Introduction:

In polyQ disease genes, the repeated triplet is always CAG, whereas, in non-polyQ disease genes, the trinucleotide repeat may be CGG, CTG, GCC, or GAA. These two types of diseases are distinguished based on the effect of the repeated sequence on gene function.

Answer 10

Summary Introduction

c.

To determine:

The reason that patients with Huntington disease have no family history.

Introduction:

The Huntington disease is an inherited disorder which causes the death of brain cells. The disease initiates in the age of 30s or 40s. It can cause impaired movement, loss of thinking ability, and psychiatric symptoms.

Answer 11

Summary Introduction

c.

To determine:

The reason that patients with Huntington disease have no family history.

Introduction:

The Huntington disease is an inherited disorder which causes the death of brain cells. The disease initiates in the age of 30s or 40s. It can cause impaired movement, loss of thinking ability, and psychiatric symptoms.

Answer 12

Summary Introduction

d.

To determine:

The result if the PCR analysis performed on single skin cells instead of a single sperm.

Introduction:

The polymerase chain reaction is a method of producing multiple copies of specific DNA sequence. It involves three steps, denaturation, annealing, and elongation. The PCR exponentially amplify the desired segment in very less time.

Answer 13

Summary Introduction

d.

To determine:

The result if the PCR analysis performed on single skin cells instead of a single sperm.

Introduction:

The polymerase chain reaction is a method of producing multiple copies of specific DNA sequence. It involves three steps, denaturation, annealing, and elongation. The PCR exponentially amplify the desired segment in very less time.

Answer 14

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Answer 15

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Answer 16

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Answer 17

Ch. 10 - Choose the phrase from the right column that best...Ch. 10 - Would you characterize the pattern of inheritance...Ch. 10 - Would you be more likely to find single nucleotide...Ch. 10 - A recent estimate of the rate of base...Ch. 10 - If you examine Fig. 10.5 on p. 344 closely, you...Ch. 10 - Approximately 50 million SNPs have thus far been...Ch. 10 - Mutations at simple sequence repeat SSR loci occur...Ch. 10 - Humans and gorillas last shared a common ancestor...Ch. 10 - Using PCR, you want to amplify an approximately 1...Ch. 10 - Prob. 10P

Solution Summary: The author explains the neurogenerative diseases caused by genes with unstable trinucleotide repeats are divided into two categories: polyQ and non-polyQ.

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