Genetics: From Genes to Genomes, 5th edition
5th Edition
ISBN: 9780073525310
Author: Leland H. Hartwell, Michael L. Goldberg, Janice A. Fischer, Leroy Hood, Charles F. Aquadro
Publisher: McGraw-Hill Education
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Chapter 10, Problem 14P
The trinucleotide repeat region of the Huntington disease locus (HD) in six individuals is amplified by PCR and analyzed by gel electrophoresis as shown in the figure at the top of the next page; the numbers to the right indicate the sizes of the PCR products in bp. Each person whose DNA was analyzed has one affected parent.
| a. | Which individuals are most likely to be affected by Huntington disease, and in which of these people is the onset of the disease likely to be earliest? |
| b. | Which individuals are least likely to be affected by the disease? |
| c. | Consider the two PCR primers used to amplify the trinucleotide repeat region. If the 5′ end of one of these primers is located 70  |
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Chapter 10 Solutions
Genetics: From Genes to Genomes, 5th edition
Ch. 10 - Choose the phrase from the right column that best...Ch. 10 - Would you characterize the pattern of inheritance...Ch. 10 - Would you be more likely to find single nucleotide...Ch. 10 - A recent estimate of the rate of base...Ch. 10 - If you examine Fig. 10.5 on p. 344 closely, you...Ch. 10 - Approximately 50 million SNPs have thus far been...Ch. 10 - Mutations at simple sequence repeat SSR loci occur...Ch. 10 - Humans and gorillas last shared a common ancestor...Ch. 10 - Using PCR, you want to amplify an approximately 1...Ch. 10 - Prob. 10P
Ch. 10 - Prob. 11PCh. 10 - Prob. 12PCh. 10 - shows three different sequences of the same...Ch. 10 - The trinucleotide repeat region of the Huntington...Ch. 10 - Prob. 15PCh. 10 - Prob. 16PCh. 10 - a. It is possible to perform DNA fingerprinting...Ch. 10 - On July 17, 1918, Tsar Nicholas II; his wife the...Ch. 10 - The figure below shows DNA fingerprint analysis of...Ch. 10 - Microarrays were used to determine the genotypes...Ch. 10 - A partial sequence of the wild-type HbA allele is...Ch. 10 - Prob. 22PCh. 10 - Prob. 23PCh. 10 - The microarray shown at the top of this page...Ch. 10 - The figure below shows the pedigree of a family in...Ch. 10 - Prob. 26PCh. 10 - Now consider a mating between consanguineous...Ch. 10 - The pedigree shown in Fig. 10.22 on p.360 was...Ch. 10 - You have identified a SNP marker that in one large...Ch. 10 - The pedigrees indicated here were obtained with...Ch. 10 - Approximately 3 of the population carries a mutant...Ch. 10 - The drug ivacaftor has recently been developed to...Ch. 10 - In the high-throughput DNA sequencing protocol...Ch. 10 - A researcher sequences the whole exome of a...Ch. 10 - As explained in the text, the cause of many...Ch. 10 - Figure 10.26 on p. 366 portrayed the analysis of...Ch. 10 - Prob. 37PCh. 10 - Table 10.2 p. 367 and Fig. 10.27 p. 367 together...Ch. 10 - The human RefSeq of the entire first exon of a...
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