Genetics: From Genes to Genomes, 5th edition
5th Edition
ISBN: 9780073525310
Author: Leland H. Hartwell, Michael L. Goldberg, Janice A. Fischer, Leroy Hood, Charles F. Aquadro
Publisher: McGraw-Hill Education
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Chapter 10, Problem 7P
Mutations at simple sequence repeat (SSR) loci occur at a frequency of 1 × 10 per locus per gamete, which is much higher than the rate of base substitutions at SNP loci (whose frequency is about 1 × 10 per
| a. | What is the nature of SSR polymorphisms? |
| b. | By what mechanism are these SSR polymorphisms likely generated? |
| c. |
Copy number variants (CNVs) also mutate at a relatively high frequency. Do these mutations occur by the same or a different mechanism than that generating SSRs? |
| d. | The SSR mutation rate is much higher than the mutation rate for new SNPs. Why then have geneticists recorded more than 50 million SNP loci but only about 100,000 SSR loci in human genomes? |
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Chapter 10 Solutions
Genetics: From Genes to Genomes, 5th edition
Ch. 10 - Choose the phrase from the right column that best...Ch. 10 - Would you characterize the pattern of inheritance...Ch. 10 - Would you be more likely to find single nucleotide...Ch. 10 - A recent estimate of the rate of base...Ch. 10 - If you examine Fig. 10.5 on p. 344 closely, you...Ch. 10 - Approximately 50 million SNPs have thus far been...Ch. 10 - Mutations at simple sequence repeat SSR loci occur...Ch. 10 - Humans and gorillas last shared a common ancestor...Ch. 10 - Using PCR, you want to amplify an approximately 1...Ch. 10 - Prob. 10P
Ch. 10 - Prob. 11PCh. 10 - Prob. 12PCh. 10 - shows three different sequences of the same...Ch. 10 - The trinucleotide repeat region of the Huntington...Ch. 10 - Prob. 15PCh. 10 - Prob. 16PCh. 10 - a. It is possible to perform DNA fingerprinting...Ch. 10 - On July 17, 1918, Tsar Nicholas II; his wife the...Ch. 10 - The figure below shows DNA fingerprint analysis of...Ch. 10 - Microarrays were used to determine the genotypes...Ch. 10 - A partial sequence of the wild-type HbA allele is...Ch. 10 - Prob. 22PCh. 10 - Prob. 23PCh. 10 - The microarray shown at the top of this page...Ch. 10 - The figure below shows the pedigree of a family in...Ch. 10 - Prob. 26PCh. 10 - Now consider a mating between consanguineous...Ch. 10 - The pedigree shown in Fig. 10.22 on p.360 was...Ch. 10 - You have identified a SNP marker that in one large...Ch. 10 - The pedigrees indicated here were obtained with...Ch. 10 - Approximately 3 of the population carries a mutant...Ch. 10 - The drug ivacaftor has recently been developed to...Ch. 10 - In the high-throughput DNA sequencing protocol...Ch. 10 - A researcher sequences the whole exome of a...Ch. 10 - As explained in the text, the cause of many...Ch. 10 - Figure 10.26 on p. 366 portrayed the analysis of...Ch. 10 - Prob. 37PCh. 10 - Table 10.2 p. 367 and Fig. 10.27 p. 367 together...Ch. 10 - The human RefSeq of the entire first exon of a...
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