This image shows the alignment of the promoter from the same gene (gene H) across multiple mammalian and bird species.  Predict how the following two mutations will affect the amount of gene expression from gene H in M. musculus (the mouse, underlined with a blue line).  A) The T marked by the first arrow is mutated to a G. This will ______expression of gene H.  Increase decrease Abolish  Not change B) The G marked by the second arrow is mutated to a A. This will _____expression of gene H.  Increase decrease Abolish  Not change

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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This image shows the alignment of the promoter from the same gene (gene H) across multiple mammalian and bird species. 

Predict how the following two mutations will affect the amount of gene expression from gene H in M. musculus (the mouse, underlined with a blue line). 

A) The T marked by the first arrow is mutated to a G. This will ______expression of gene H. 

Increase

decrease

Abolish 

Not change

B) The G marked by the second arrow is mutated to a A. This will _____expression of gene H. 

Increase

decrease

Abolish 

Not change

B
Mammals
Birds
H. sapiens
E. caballus
B. taurus
O. aries
C. hircus
S. scrofa
O. cuniculus
M. musculus
G. gallus
C. chinensis
CAAT box
AI
TATA box
TATA box
AAGACCAATCATAGATCCTGACGACACTTG--TCTCATCTAAGTTGGAATATAAAAAGCCACTTGGAATACATATAAAA
AGGAGCCAATCATAGATCCTGACGACACTTG--TCTCATCAAAGTTGGAATATAAAAAGCCACTTGGAATACATATAAAA
AAGACCAATCACAGATCCCGACGACACTTG--TCTCATCAAAGTTGGAATATAAAAAGCCACTTGGAATACATATAAAA
AAGACCAATCACAGATCCCGACGACACTTG--TCTCATCAAAGTTGGAATATAAAAAGCCACTTGGAATACATATAAAA
AAGACCAATCACAGATCCCGACGACACTTG--TCTCATCAAAGTTGGAATATAAAAAGCCACTTGGAATACATATAAAA
AAGACCAATCATAGATCCTGACGACACTTG--TCTCATCAAG--TGGAATATAAAAAGCCACTTGGAATACATATAAAA
AAGACCAATCATAGACCCTGACGACACTTG--TCTCATCTAAGTTGGAATATAAAAAGCCACTTGGAATACAGTATCAAAG
AGGAGCCAATCATAGATCCTGACGACACTTG--TCTCCTCTAAGTTGGAATATAAAAAGCCACTTGGAATACAGTATACAGG
AACAACCAATCGTCGGTTTTGACGACATGAG--CCTAATCAAAGTTGGAGTATAAAAGCCCCCTTGGCA-----TATATAAG
AACAACCAATCGTCGGTTTTGACGACATGAG--CCTAATCAAAGTCGCAGTATAAAAGCCCCCTTGGCA- ---TATAAAA
-TATATAAG
A. platyrhynchos AACAACCAATCGTTGGTTTTGACGACATGAG--CCTAATCAAAGTTGGAGTATAAAAGCCCCCTTGGAA-
A. anser
AACAACCAATCGTTGGTTTTGACGACATGAG--CCTAATCAAAGTTGGAGTATAAAAGCCCCCTTGGAA-----TATATAAG
Transcribed Image Text:B Mammals Birds H. sapiens E. caballus B. taurus O. aries C. hircus S. scrofa O. cuniculus M. musculus G. gallus C. chinensis CAAT box AI TATA box TATA box AAGACCAATCATAGATCCTGACGACACTTG--TCTCATCTAAGTTGGAATATAAAAAGCCACTTGGAATACATATAAAA AGGAGCCAATCATAGATCCTGACGACACTTG--TCTCATCAAAGTTGGAATATAAAAAGCCACTTGGAATACATATAAAA AAGACCAATCACAGATCCCGACGACACTTG--TCTCATCAAAGTTGGAATATAAAAAGCCACTTGGAATACATATAAAA AAGACCAATCACAGATCCCGACGACACTTG--TCTCATCAAAGTTGGAATATAAAAAGCCACTTGGAATACATATAAAA AAGACCAATCACAGATCCCGACGACACTTG--TCTCATCAAAGTTGGAATATAAAAAGCCACTTGGAATACATATAAAA AAGACCAATCATAGATCCTGACGACACTTG--TCTCATCAAG--TGGAATATAAAAAGCCACTTGGAATACATATAAAA AAGACCAATCATAGACCCTGACGACACTTG--TCTCATCTAAGTTGGAATATAAAAAGCCACTTGGAATACAGTATCAAAG AGGAGCCAATCATAGATCCTGACGACACTTG--TCTCCTCTAAGTTGGAATATAAAAAGCCACTTGGAATACAGTATACAGG AACAACCAATCGTCGGTTTTGACGACATGAG--CCTAATCAAAGTTGGAGTATAAAAGCCCCCTTGGCA-----TATATAAG AACAACCAATCGTCGGTTTTGACGACATGAG--CCTAATCAAAGTCGCAGTATAAAAGCCCCCTTGGCA- ---TATAAAA -TATATAAG A. platyrhynchos AACAACCAATCGTTGGTTTTGACGACATGAG--CCTAATCAAAGTTGGAGTATAAAAGCCCCCTTGGAA- A. anser AACAACCAATCGTTGGTTTTGACGACATGAG--CCTAATCAAAGTTGGAGTATAAAAGCCCCCTTGGAA-----TATATAAG
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