lease help with all of these! thank you so much! Neutral regions of a species’ genome that are distant from any selected sites have a pairwise diversity (?) of 0.01. Other regions of the genome have reduced genetic variation, and selective sweeps could be responsible for the reduction. Assume that selective sweeps happen at a rate of 10^-10 per bp, and they take 500 generations to reach fixation. The recombination rate in regions where selective sweeps might occur is 10^-8 per bp. The effective population size of the species is 10^5. A. Find the expected genetic diversity (? per bp) in regions where selective sweeps might be occurring. B. Find the deleterious mutation rate (per bp) that would be required to produce an equivalent reduction in genetic diversity as a result of background selection (BGS)? Assume the same recombination rate as abov
Molecular Techniques
Molecular techniques are methods employed in molecular biology, genetics, biochemistry, and biophysics to manipulate and analyze nucleic acids (deoxyribonucleic acid (DNA) and ribonucleic acid (RNA)), protein, and lipids. Techniques in molecular biology are employed to investigate the molecular basis for biological activity. These techniques are used to analyze cellular properties, structures, and chemical reactions, with a focus on how certain molecules regulate cellular reactions and growth.
DNA Fingerprinting and Gel Electrophoresis
The genetic makeup of living organisms is shown by a technique known as DNA fingerprinting. The difference is the satellite region of DNA is shown by this process. Alex Jeffreys has invented the process of DNA fingerprinting in 1985. Any biological samples such as blood, hair, saliva, semen can be used for DNA fingerprinting. DNA fingerprinting is also known as DNA profiling or molecular fingerprinting.
Molecular Markers
A known DNA sequence or gene sequence is present on a chromosome, and it is associated with a specific trait or character. It is mainly used as a genetic marker of the molecular marker. The first genetic map was done in a fruit fly, using genes as the first marker. In two categories, molecular markers are classified, classical marker and a DNA marker. A molecular marker is also known as a genetic marker.
DNA Sequencing
The most important feature of DNA (deoxyribonucleic acid) molecules are nucleotide sequences and the identification of genes and their activities. This the reason why scientists have been working to determine the sequences of pieces of DNA covered under the genomic field. The primary objective of the Human Genome Project was to determine the nucleotide sequence of the entire human nuclear genome. DNA sequencing selectively eliminates the introns leading to only exome sequencing that allows proteins coding.
Please help with all of these! thank you so much!
Neutral regions of a species’ genome that are distant from any selected sites have a
pairwise diversity (?) of 0.01. Other regions of the genome have reduced
and selective sweeps could be responsible for the reduction. Assume that selective sweeps
happen at a rate of 10^-10 per bp, and they take 500 generations to reach fixation. The
recombination rate in regions where selective sweeps might occur is 10^-8 per bp. The
effective
A. Find the expected genetic diversity (? per bp) in regions where selective sweeps
might be occurring.
B. Find the deleterious mutation rate (per bp) that would be required to produce an
equivalent reduction in genetic diversity as a result of background selection (BGS)?
Assume the same recombination rate as above.
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