Neutral regions of a species’ genome that are distant from any selected sites have a pairwise diversity (π) of 0.01. Other regions of the genome have reduced genetic variation, and selective sweeps could be responsible for the reduction. Assume that selective sweeps happen at a rate of 10^-10 per bp, and they take 500 generations to reach fixation. The recombination rate in regions where selective sweeps might occur is 10^-8 per bp. The effective population size of the species is 10^5. A. Find the expected genetic diversity (? per bp) in regions where selective sweeps might be occurring. B. Find the deleterious mutation rate (per bp) that would be required to produce an equivalent reduction in genetic diversity as a result of background selection (BGS)? Assume the same recombination rate as above. Lastly, distinguish between selective sweeps or BGS being responsible for the reduction in genetic diversity

Neutral regions of a species’ genome that are distant from any selected sites have a pairwise diversity (π) of 0.01. Other regions of the genome have reduced genetic variation, and selective sweeps could be responsible for the reduction. Assume that selective sweeps happen at a rate of 10^-10 per bp, and they take 500 generations to reach fixation. The recombination rate in regions where selective sweeps might occur is 10^-8 per bp. The effective population size of the species is 10^5. A. Find the expected genetic diversity (? per bp) in regions where selective sweeps might be occurring. B. Find the deleterious mutation rate (per bp) that would be required to produce an equivalent reduction in genetic diversity as a result of background selection (BGS)? Assume the same recombination rate as above. Lastly, distinguish between selective sweeps or BGS being responsible for the reduction in genetic diversity

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter14: Biotechnology And Society

Section: Chapter Questions

Problem 3CS: Can DNA profiling identify the source of a sample with absolute certainty? Because any two human...

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