Neutral regions of a species’ genome that are distant from any selected sites have a pairwise diversity (π) of 0.01. Other regions of the genome have reduced genetic variation, and selective sweeps could be responsible for the reduction. Assume that selective sweeps happen at a rate of 10^-10 per bp, and they take 500 generations to reach fixation. The recombination rate in regions where selective sweeps might occur is 10^-8 per bp. The effective population size of the species is 10^5. A. Find the expected genetic diversity (? per bp) in regions where selective sweeps might be occurring. B. Find the deleterious mutation rate (per bp) that would be required to produce an equivalent reduction in genetic diversity as a result of background selection (BGS)? Assume the same recombination rate as above. Lastly, distinguish between selective sweeps or BGS being responsible for the reduction in genetic diversity
Neutral regions of a species’ genome that are distant from any selected sites have a
pairwise diversity (π) of 0.01. Other regions of the genome have reduced
and selective sweeps could be responsible for the reduction. Assume that selective sweeps
happen at a rate of 10^-10 per bp, and they take 500 generations to reach fixation. The
recombination rate in regions where selective sweeps might occur is 10^-8 per bp. The
effective
A. Find the expected genetic diversity (? per bp) in regions where selective sweeps
might be occurring.
B. Find the deleterious mutation rate (per bp) that would be required to produce an
equivalent reduction in genetic diversity as a result of background selection (BGS)?
Assume the same recombination rate as above.
Lastly, distinguish between selective sweeps or BGS being responsible for the reduction in genetic diversity
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