Briefly explain how Genome Wide Association Studies (GWAS) are done. Then, using this example of a Manhattan Plot explain what each of the X-axis and the Y-axis signifies in a GWAS.

Q: Discuss the similarities and differences between forward and reverse genetic approaches, and when…

A: Differences between forward and reverse genetics are as follows:Forward genetics involves the…

Q: Why is genome database and annotation relevant to Genome sequencing?   Are there any examples?

A: Genome: the set of genes. Genome database: it is the collection of all information on the human…

Q: You complete a comparative transcriptomics experiment, where RNA from a plant sample grown in sandy…

A: The researchers compared the gene expression differences between plants cultivated in silty soil and…

Q: List three rules for designing primers?

A: A primer is short ,single strand DNA sequence used in the polymerase chain reaction. Primers are…

Q: For a coding gene, purifying (negative) selection will result in more synonymous (silent) site…

A: Purifying selection is the most predominant form of natural selection or negative selection. As it…

Q: You are engineering a new vector that contains a screenable marker that can be used for blue/white…

A: Three important points to remember about the blue-white test: a special substrate is used which is…

Q: You are attempting to prepare a single gene knockout library using the pRL27 transposon system. You…

A: * Given that prepared a single gene knockout library using the pRL27 transposon system. *Then grows…

Q: How the amplification of other genomic methods such as optical mapping helps to overcome the…

A: The amplification of other genomic methods like optical mapping  has definitely improved the…

Q: List other methods of reverse genetics available in S. cerevisiae, Drosophila, Arabidopsis, and…

A: Saccharomyces cerevisiae commonly known as the yeast  are micro organism with application in…

Q: A very common molecular biology research method is to analyze cell or tissue homogenates by…

A: In molecular biology research, SDS-polyacrylamide gel electrophoresis (SDS-PAGE) and immunoblotting,…

Q: What is a repetitive element in genomics?  What are the types of repetitive elements?  What is their…

A: The amount  of DNA present in a cell of a person is called as genome. DNA is made up of nucleotides…

Q: What is the difference of intragenic and intergenic regions? Please explain with drawing.

A: In the intricate tapestry of the genome, the terms "intragenic" and "intergenic" encapsulate…

Q: What are ‘Selectable marker’? What is their use in genetic engineering?

A: Genetic engineering is a technique to manipulate the genetic content of an organism resulting in…

Q: Exaplain the two methods to study the contents of transcriptomes which are microarray analysis and…

A: Transcriptome analysis may be used to find novel genes and isoforms that are not already cataloged…

Q: Meta analysis C9orf72 Known Novel • 20 15 10 SARM1UNC13A МОВР GPX3-TNIP1 -LOC101927815- SCFD1- 5 CO…

A: ALS (Amyotrophic Lateral Sclerosis) is a group of rare neurological disease. It involves  the motor…

Q: LINEs and SINEs are repetitive sequences in humans that as retrotransposons, can also insert into…

A: Transposable elements (TEs) are DNA sequences that can change their position from one location of…

Q: What is the difference between using genome build hg18 and hg19 in Genome-wide SNP arrays?

A: SNP (Single nucleotide protein) array is a type of DNA (deoxyribonucleic acid) microarray which is…

Q: What is homologous recombination and where/when does it typically take place in an organism.…

A: Homologous recombination is a genetic exchange process that occurs between two similar or identical…

Q: High throughput whole genome sequencing, RNA-seq and ChIP-seq have all been made possible by the…

A: Genetic technologies have achieved great advancements in the recent years. One amongst many of those…

Q: 1) Enhanced GFP protein has: An excitation peak at 488nm and emits maximally at 507nm. An excitation…

A: Answer 1.  Answer. 1). Enhanced GFP protein has an excitation peak at 488nm and emits maximally…

Q: The following figure shows a screen shot  from the UCSC Genome Browser, focusing  on a region of the…

A: MFAP3L MFAP3L gene is an abbreviated form of Mircrofibril associated Protein 3 Like gene . The gene…

Q: 3) You have identified an interesting mutant in gene P. Using a Punnett square, demonstrate the…

A: The pure breeding lines of mutant and wild type organism must be crossed to determine if the…

Q: E. coli strain BW25113 can grow on (D) Arg as the sole carbon source. A scientist  working with you…

A: Obtain the genomic  from the mice cells that encode for the protease of interest.Fragment the…

Genome annotation

The technique of linking biological information to genome sequences is termed genome annotation. Gene annotation is the method of identifying gene locations and coding sections. It helps us understand what these genes are doing in the body through establishing structural characteristics and linking them to the actions of various proteins.