After comparing the whole genome sequencing results from a candidate that you suspect has a mutation that causes a downstream shift in start site selection to the parent strain to rule out pre-existing mutations, you are left with the following list of missense mutations. In 100 words or less, explain which of these mutations you believe is likely responsible for the transcription-related defects observed in your candidate strain and why you have ruled out the others. PKH1 F187I SHC1 K233E GUA1 P394L
Gene Interactions
When the expression of a single trait is influenced by two or more different non-allelic genes, it is termed as genetic interaction. According to Mendel's law of inheritance, each gene functions in its own way and does not depend on the function of another gene, i.e., a single gene controls each of seven characteristics considered, but the complex contribution of many different genes determine many traits of an organism.
Gene Expression
Gene expression is a process by which the instructions present in deoxyribonucleic acid (DNA) are converted into useful molecules such as proteins, and functional messenger ribonucleic (mRNA) molecules in the case of non-protein-coding genes.
After comparing the whole genome sequencing results from a candidate that you suspect has a mutation that causes a downstream shift in start site selection to the parent strain to rule out pre-existing mutations, you are left with the following list of missense mutations. In 100 words or less, explain which of these mutations you believe is likely responsible for the transcription-related defects observed in your candidate strain and why you have ruled out the others.
PKH1 F187I
SHC1 K233E
GUA1 P394L
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