With several molecular biology techniques, researchers identified that the intertwined sequence could be naturally transcribed using a promoter located 13 kilobases upstream that of p16INK4A. In addition, the transcription of this gene results in a primary transcript that is read in a different reading frame and is alternatively spliced compared to the transcript of p16INK4A. The resulting protein has been called ARF (Alternative Reading Frame). In your own words and with a diagram, describe the DNA, RNA and proteins encoded in this region.
Gene Interactions
When the expression of a single trait is influenced by two or more different non-allelic genes, it is termed as genetic interaction. According to Mendel's law of inheritance, each gene functions in its own way and does not depend on the function of another gene, i.e., a single gene controls each of seven characteristics considered, but the complex contribution of many different genes determine many traits of an organism.
Gene Expression
Gene expression is a process by which the instructions present in deoxyribonucleic acid (DNA) are converted into useful molecules such as proteins, and functional messenger ribonucleic (mRNA) molecules in the case of non-protein-coding genes.
With several molecular biology techniques, researchers identified that the intertwined sequence could be naturally transcribed using a promoter located 13 kilobases upstream that of p16INK4A. In addition, the transcription of this gene results in a primary transcript that is read in a different reading frame and is alternatively spliced compared to the transcript of p16INK4A. The resulting protein has been called ARF (Alternative Reading Frame). In your own words and with a diagram, describe the DNA, RNA and proteins encoded in this region.
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