A researcher performed transcriptional profiling on control and treatment groups. The lab found that 350 genes changed significantly with treatment. To validate these findings, extra mRNA was saved and PCR was used to measure 7 of the 350 significant genes. All 7 showed the same direction of change by PCR as observed in the transcriptional profile analysis. The author states that this has improved the FDR, at least for these 7 genes. Is the author correct?
A researcher performed transcriptional profiling on control and treatment groups. The lab found that 350 genes changed significantly with treatment. To validate these findings, extra mRNA was saved and PCR was used to measure 7 of the 350 significant genes. All 7 showed the same direction of change by PCR as observed in the transcriptional profile analysis. The author states that this has improved the FDR, at least for these 7 genes. Is the author correct?
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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A researcher performed transcriptional profiling on control and treatment groups. The lab found that 350 genes changed significantly with treatment. To validate these findings, extra mRNA was saved and PCR was used to measure 7 of the 350 significant genes. All 7 showed the same direction of change by PCR as observed in the transcriptional profile analysis. The author states that this has improved the FDR, at least for these 7 genes. Is the author correct?
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