The human gene for hemophilia is on the X chromosome. Below is a pedigree from a family afflicted with hemophilia. The man with blackened symbol (III-1) has hemophilia. To help with genetic diagnosis, a probe that detects an RFLP (restriction fragment length polymorphism) on the X chromosome is used. This probe detects either a 7 kb restriction enzyme fragment or 3 kb and 4 kb restriction enzyme fragments. The RFLP pattern for all the members of the pedigree is shown. The recombination distance between the RFLP and the hemophilia locus is 40%. What is the chance that their unborn child (III-7) is affected? 4 kb 3 kb Select one: a. 10% b. 20% C. 40% d. 60% e. 80% f. 90% g. None of these above II II

The human gene for hemophilia is on the X chromosome. Below is a pedigree from a family afflicted with hemophilia. The man with blackened symbol (III-1) has hemophilia. To help with genetic diagnosis, a probe that detects an RFLP (restriction fragment length polymorphism) on the X chromosome is used. This probe detects either a 7 kb restriction enzyme fragment or 3 kb and 4 kb restriction enzyme fragments. The RFLP pattern for all the members of the pedigree is shown. The recombination distance between the RFLP and the hemophilia locus is 40%. What is the chance that their unborn child (III-7) is affected? 4 kb 3 kb Select one: a. 10% b. 20% C. 40% d. 60% e. 80% f. 90% g. None of these above II II

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Description: The human gene for hemophilia is on the X chromosome. Below is a pedigree from a familyafflicted with hemophilia. The man with blackened symbol (III-1) has hemophilia. To help withgenetic diagnosis, a probe that detects an RFLP (restriction fragment

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Mitochondrial Mutations

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The human gene for hemophilia is on the X chromosome. Below is a pedigree from a family
afflicted with hemophilia. The man with blackened symbol (III-1) has hemophilia. To help with
genetic diagnosis, a probe that detects an RFLP (restriction fragment length polymorphism) on
the X chromosome is used. This probe detects either a 7 kb restriction enzyme fragment or 3
kb and 4 kb restriction enzyme fragments. The RFLP pattern for all the members of the
pedigree is shown. The recombination distance between the RFLP and the hemophilia locus is
40%. What is the chance that their unborn child (III-7) is affected?
4 kb
3 kb
Select one:
a. 10%
b. 20%
C. 40%
d. 60%
e. 80%
f. 90%
g. None of these above
II
II

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